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Adenosin a nádorová imunoterapie
FREJLACHOVÁ, Andrea
The aim of this bachelor thesis was to study the immunosuppressive effects of adenosine and the use this knowledges in cancer immunotherapy. The impact of enzymatic removal of adenosine on efficacy of cancer immunotherapy was examined using murine pancreatic model Panc02.
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Regulační T lymfocyty a nádorová onemocnění
SKALIČKOVÁ, Markéta
The main aim of this thesis was to study the role of regulatory T cells in cancer. Their presence, importance, and mechanism of their action were studied as well. The practical part was focused on reduction of bigger tumors and suppressing regulatory T-cell effects. The combination of TLR agonists, agonistic CD40 antibody and anti-CTLA-4 was studied on a mouse model of pancreatic adenocarcinoma.
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Imunoterapie melanomu a pankreatického adenokarcinomu na myším modelu
JANDOVÁ, Linda
The aim of this thesis is focused on possibilities of cancer immunotherapy which was studied in mouse B16-F10 melanoma model and in mouse Panc02 pancreatic adenocarcinoma model. We compared the effect of various compounds stimulating both innate and adaptive immunity using in vivo and in vitro experiments. The study also monitors incidence of metastasis.
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Úloha vrozené a získané imunity v imunoterapii melanomu a pankreatického adenokarcinomu
NEDBALOVÁ, Pavla
This study examines the role of innate and adaptive immunity in the immunotherapy based on the combination of the ligands stimulating phagocytosis anchored in the tumour cells membrane and the mixture of TLR agonists. This immunotherapy is primarily focused on the innate immunity activation and induces strong inflammatory infiltration, which neutrophils and NK cells are part of. Therefore, the next aim of this study was to evaluate the anti-tumour activity of neutrophils and NK cells. For examination malignant melanoma and pancreatic adenocarcinoma mouse tumour models were used.
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