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Pre-transfusion laboratory examination of patients with AIHA and multiple myeloma
 INGRIŠOVÁ, Karolína
This bachelor thesis follow up laboratory pre-transfusion tests in the special imunohematology lab for patients with AIHA diagnosis and multiple myeloms. For said patients, compatibility of the erythrocyte tranfusion must be maintained using special procedures. For AIHA patients, that means removal of patient's auto-antibodies by saturating the patient's plasma sample. As for patients with multiple myeloma, treatment of erythrocytes (either diagnostic or donor) with DTT is needed to remove false positivity caused by other treatments (such as administration of Daratumumab). Theoretical part consists of explanation of the basic immunohematological terms followed by thorough description of tests needed for patients with mentioned problematic diagnosis. Practical parts describes all laboratory procedures of each individual pre-transfusion tests including special ones for patients with AIHA and MM. This part also contains evaulation and analysis of all patients with AIHA and MM examined at the transfusion department of the University Hospital in Pilsen during the years 2021 and 2022. At the end of this part, all aquired data are evaluated using charts and graphs. End of this thesis contains summary and importance of tests performed for patients with the diagnosis of AIHA and MM, including answers for previously set research questions.
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