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The incidence of secondary tumors after irradiation for carcinoma of the uterine body.
TESAŘOVÁ, Lenka
ANNOTATION: Malignant tumours of the corpus uteri are among the most frequently occurring gynaecological conditions. Endometrial carcinoma represents 96{--}98% of all malignities in corpus uteri tumours. Occurrence of this condition in the Czech Republic: in 2007, 1726 new cases were diagnosed, which represents approximately 32.7 cases per 100 thousand women. Almost 75% of the patients are diagnosed in the first stage of the disease. The age median of the patients with a diagnosed tumour of the corpus uteri is 61 years. Secondary tumours occur from mutations several years after radiation exposure. They result from the previously administered chemotherapy or radiotherapy leading to the damage to the genetic information in the cells. The mutation affects the cells that relate to the formation of secondary malignities. The aim of my bachelor{\crq}s thesis is to find out about the occurrence of the secondary tumour with cancer of the corpus uteri among those who received radiotherapy at the Department of Oncology at Hospital České Budějovice between years 1978-98. In my thesis I evaluated the number of secondary tumours, time of their occurrence, relative risks, and whether they are located within or outside the irradiated field. The thesis is divided in two main parts: a theoretical part where I deal with the tumour itself, radiotherapy, and radiobiology; and a practical part that presents concrete statistics issuing from the aim of my work. I found out that secondary tumours occur more frequently outside the irradiated area. The results suggest that secondary tumours may occur from the effects of the ionising radiation on the organism. This probably relates to the fact that there are lethal changes within the area exposed to radiation whereas in areas receiving low doses of radiation the cells are damaged, which may, after many years, lead to the occurrence of secondary tumours. I chose this topic also to emphasise the fact that besides the curing of the primary tumour one also needs to pay attention to dispensing a routine that may aid the early detection of further tumours
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