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National Repository of Grey Literature 1 records found  Search took 0.01 seconds. 
Aperiodic component of EEG power spectrum in Parkinson’s disease patients treated by deep brain stimulation
 Chrásková, Sofie Hedvika ; Gajdoš, Martin (referee) ; Lamoš, Martin (advisor)
Parkinson's disease (PD) is one of the most common neurodegenerative diseases. The number of diagnosed patients has doubled in the last 30 years. Symptomatic treatment primarily includes pharmacological therapy, as well as modulation of brain activity using deep brain stimulation (DBS). This work focuses on the electrophysiological changes in patients treated with DBS, which may aid the development of this highly successful therapy. As part of the practical section of the work, the effect of DBS on the so-called aperiodic component of the power spectrum of the EEG signal was examined. The results of the work demonstrate that the long-term effects of DBS have an impact on the aperiodic component. Likewise, the work proves that changes in the aperiodic component can be observed when comparing stimulation on and off. These statements support the conclusions of the latest research, which highlight the potential of the aperiodic component as an input signal for individual therapy of Parkinson's disease using adaptive DBS.
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