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Laboratory Diagnostics of Multiple Myeloma
ČERNÝ, Jakub
The bachelor thesis on the topic Laboratory diagnostics of multiple myeloma is divided into theoretical and practical parts. In the theoretical part I introduce the hematooncological disease multiple myeloma, its laboratory diagnostics, which include biochemical, hematological, immunological, genetic and histological tests. In addition, I also present other diagnostic methods - skeletal imaging (X-ray, CT, PET/CT). I also present other pathologies that are closely related to the problem and are associated with monoclonal gammopathy. At the end of the theoretical part I briefly inform about the treatment options for this disease. For the bachelor thesis 4 objectives were set. The first aim was to summarize the laboratory testing methods currently used to diagnose MM. The second aim was to map the diagnostic procedure for the first detection of MM using a specific patient as an example. The third aim was to highlight the variability of initial findings and disease course in the form of case reports. The fourth and final aim was to use data obtained from the Institute's own department (laboratory + haematology outpatient clinic) to answer several research questions. To achieve the results of the research investigation, quantitative research methods were used by retrospective analysis of available laboratory data from LIS. Qualitative research technique of data analysis was used to write individual case reports and complete patient diagnosis. In the discussion and in the conclusion of the bachelor thesis, the results of the research questions and the evaluation of the fulfilment of the stated objectives of the thesis are summarised. Finally, the expected contribution of the bachelor thesis in current laboratory and clinical diagnosis of the disease is mentioned.
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