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Invasion of the host cell by the parasitic protist Plasmodium falciparum.
Charvátová, Klára ; Doležal, Pavel (advisor) ; Tůmová, Pavla (referee)
Plasmodium falciparum is an intracellular parasite that causes tropical malaria. Although plasmodium is not a problem in the middle latitudes, in tropical and subtropical regions it poses a great health threat. This specifically concerns little children, which constitute more than a half of the victims. This thesis discusses the invasion of the red blood cell by a merozoite, which is a key step of the parasite life cycle responsible for the disease development. The main part of the thesis deals with proteins secreted by organelles of the invasive apparatus of plasmodium cell. It is preceded by a chapter introducing basic information on P. falciparum and malaria. The end of the thesis contains a chapter on the parasite exit from the red blood cell. Key words Invasion, plasmodium, parasite, merozoite, red blood cell, tight junction, gliding motility, apical complex, micronemes, rhoptries
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