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Magnetic nanoparticles of iron oxides for medicine
Kubániová, Denisa ; Kohout, Jaroslav (advisor) ; Mašláň, Miroslav (referee) ; Šepelák, Vladimír (referee)
Magnetic nanoparticles of iron oxides, particularly those of ferric oxides, magnetite, substituted variants, including functional derivatives, have attracted significant interest because of promis- ing capabilities in emerging diagnostic imaging methods and novel therapeutic interventions. In addition to the rapid development of syntheses and functionalization methods, a comprehen- sive understanding of their fundamental physical characteristics and the complex link among composition, microstructure, magnetic properties, and relaxation characteristics is pivotal for the rational design of well-defined magnetic nanoparticle systems. Generally, the magnetic behavior of nanoparticles deviates from bulk materials not only due to finite-size and surface effects but also by the occurrence of new crystal structures (polymorphs) and metastable states, such as non-equilibrium cation distribution. The doctoral thesis investigates the key physical characteristics of selected nanoparticle systems (simple ferric oxides of various crystal struc- ture and morphology; Zn-, Co- and Mn-substituted magnetite-maghemite; coated by various hydrophilic and biologically inert surface layers), primarily by 57 Fe Mössbauer spectroscopy and supplemented by other available techniques. For that purpose, Mössbauer spectroscopy that...
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