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Infektivita sporozoitů kryptosporidií s ohledem na lokalizaci vývojového cyklu
 SKLENÁŘOVÁ, Eliška
Cryptosporidium, belonging to the phylum Apicomplexa, are parasites found across all classes of vertebrates worldwide, including humans. They infect the gastrointes-tinal tract, leading to acute or chronic diarrheal disease, especially in individuals with weakened immune systems. Infection spreads through contaminated water, food, or direct contact. A main aspect is the excystation process, which allows the parasites to infect the host. The study focuses on the environmental conditions of the gastrointestinal tract where Cryptosporidium excystation occurs and the factors ne-cessary for this process. Research has shown that different species of Cryptosporidi-um exhibit variability in excystation depending on their location in the host's body. The results suggest that different species of Cryptosporidium excyst most efficiently in different parts of the digestive tract, thus proper excystation localization is crucial for successful infection. Experiments have shown that environmental temperature and pH play a key role. Research indicates the existence of a protective factor in the host's body that limits excystation in the digestive tract. The study also examines the prepatent period of individual Cryptosporidium species and finds that the method of inoculation does not affect the length of this period. Understanding the excystation process and the conditions that influence it is crucial for the development of effecti-ve cryptosporidiosis therapy.
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