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Correlation of morphokinetic parameters of human preimplantation embryos with their chromosomal status
Kosařová, Zuzana ; Jelínková, Ladislava (advisor) ; Knytl, Martin (referee)
A significant amount of human preimplantation embryos is aneuploid. Preimplantation genetic testing of aneuploidies (PGT-A) enables us to examine the number of chromosomes in a few trophectoderm cells biopsied from developing embryos, and only euploid embryos are then recommended to be transferred. Biopsy of trophectoderm cells is an invasive method, PGT is quite expensive, the examination is not performed at all patients. Therefore, non-invasive methods for determining the highest quality embryos are searching. Non- invasive continual monitoring in a time-lapse system is able to observe the morphokinetic parameters of embryonic development, and can select the best developing embryos with a good prognosis for successful implantation. However, there is still the question of whether and how morphokinetic parameters and embryonic ploidy correlate. Most studies on this topic show that a combination of both of these approaches is the best way for selecting the highest quality embryo for transfer.
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The Human Embryo in the Perspective of Reproductive Medicine
Halabicová, Věra ; Ovečka, Libor (advisor) ; Matějek, Jaromír (referee) ; Opatrný, Dominik (referee)
Title: The Human Embryo in the Perspective of Reproductive Medicine. Since when one begins to be a human person? In this work, we take into account the issues, which in most cases lead many people to resort to the reproductive medicine, which generally is referred to as the infertility problems. But in some techniques, the reproductive medicine loses up to 80% of human embryos. In the minds of many people, the human embryo is seen only as a cluster of cells. However, is it really just a cluster of cells, or is it already a person at an early stage of development? As far as one is already man, is he now also the human being, of whom are in our Western culture related rights, especially the right to life? Could we then say with a clear conscience that with these techniques we are acting ethically? We dividend our work into six chapters. In the first and second chapter, we will be briefly acquainted with the issues of infertility, of the reproductive medicine techniques, with the development of the human embryo and with handling of the embryos in the course of these techniques. In the third charter, we will present the two major ethical models in our cultural area that have a different point of view on the status of the human embryo. In the fourth chapter, we will look at how to the question of the...
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