|
|
Natural drugs in cancer treatment and their cytotoxicity
Hájková, Tereza ; Raudenská, Martina (referee) ; Provazník, Ivo (advisor)
The thesis deals with the natural substances in context with the cancer disease. The natural substances have a positive effect on the human organism and they are able to influence the viability and the growth of the cancer cells. The main mechanical device is to influence the mechanisms needed to start the apoptosis of the cancer cells and stopping further proliferation. The cancer cell lines utilization in the cancer disease is discussed in the thesis too. The thesis states common methods of determining the natural substances cytotoxicity. For the experimental part of the thesis it was chosen the MTT test method and the xCELLigence system for monitoring in real time. The mechanical device of the tested substance capsaicin in application on the prostate cell lines, tumorous PC3 and nontumorous PNT1A influence will be observed within the experimental part of the thesis.
|
|
|
Theragnostics - new methods in nuclear medicine
PROCHÁZKOVÁ, Michaela
The main topic of the bachelor thesis is theragnostics - new methods in nuclear medicine. Theragnostics is a personalized treatment strategy that combines diagnostics with therapy and finds application primarily in the treatment of cancer. Theragnostics as a medical field is still evolving. The aim of this work was to map the practical use of current indications of theragnostic methods in nuclear medicine. The theoretical part of the thesis defines the concept of theragnostics and theragnostic methods containing nanoparticles and radionuclides. There is described the use of radionuclide theragnotics in clinical practice, especially in the treatment of thyroid gland, neuroendocrine tumors and prostate cancer. In this part of the thesis there are also clinical studies for theragnotic practice. Furthermore in the theoretical part of the thesis is maped the practical use of current indications of theragnotic methods, as well as possible future perspectives of theragnotic treatment. The theoretical part is processed from professional publications and articles. The practical part of the work focuses on the awareness of radiology assistants about this new treatment method. The respondents were radiology assistants across hospitals. There were 32 respondents involved to complete the research questions for the questionnaire survey. The evaluation from the collected data of the questionnaire survey is in the form of the percentage success of radiological assistants. The overall concept of this bachelor's thesis can serve as a study material for university students in the field of radiology assistant.
|
|
|
Male infertility in context of testicular cancer
Cimlerová, Markéta ; Komrsková, Kateřina (advisor) ; Truksa, Jaroslav (referee)
This bachelor thesis focuses on male infertility in a connection to testicular cancer. Testicular cancer is the most common malignancy among young men in a reproductive age and the worldwide incidence of testicular cancer is on the rise. A lot of attention is also given to an increasing rate of infertility in a context of testicular cancer. For these reasons, the aim of this thesis is to clarify several non-physiological changes, such as hormone levels, spermatogenesis and sperm parameters, which take place in a male body and influence the chance to become a biological father. These pathological changes can be due to the disease itself but also due to the treatment. A cryopreservation of semen is also going to be discussed as the way to preserve male fertility and as an option for couples with the infertility problems due to male factor which rely on help of the assisted reprodiction. Kye words: testicular cancer, cancer treatment, male infertility, sperm parameters, mitochondria, assisted reproduction
|
|
|
Natural drugs in cancer treatment and their cytotoxicity
Hájková, Tereza ; Raudenská, Martina (referee) ; Provazník, Ivo (advisor)
The thesis deals with the natural substances in context with the cancer disease. The natural substances have a positive effect on the human organism and they are able to influence the viability and the growth of the cancer cells. The main mechanical device is to influence the mechanisms needed to start the apoptosis of the cancer cells and stopping further proliferation. The cancer cell lines utilization in the cancer disease is discussed in the thesis too. The thesis states common methods of determining the natural substances cytotoxicity. For the experimental part of the thesis it was chosen the MTT test method and the xCELLigence system for monitoring in real time. The mechanical device of the tested substance capsaicin in application on the prostate cell lines, tumorous PC3 and nontumorous PNT1A influence will be observed within the experimental part of the thesis.
|
guest ::
