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Advanced glycation endproducts and their receptor (RAGE) in Alzheimer's disease
Štorkánová, Jesika ; Chlebek, Jakub (advisor) ; Opletal, Lubomír (referee)
Štorkánová, J.:Advanced glycation endproducts and their receptor RAGA IN Alzheimer's disease, Bachelor thesis, Charles University in Prague, Faculty of Pharmacy in Hradec Kralove, Department of Pharmaceutical Botany and Ecology, Hradec Kralove 2016, 97 p. Alzheimer's disease (AD) is the most common cause of dementia of late life. AD manifests as progressive memory impairment followed by a gradual decline in other cognitive abilities. For AD is characteristic the abnormal accumulation or aggregation of proteins. Advanced glycation endproducts (AGEs) are a heterogenous group of compounds that are formed when carbonyl group of reducing sugars reacts by a non-enzymatic reaction with amino acids in proteins, lipids and nucleic acids. The formation of AGEs promotes the deposition of proteins due to the protease resistant crosslinking, therefore is difficult to eliminace them from organism. AGEs can be detected in pathological deposits such as amyloid plaques and neurofibrillary tangles, which are prominent pathological feature sof AD. The formation of AGEs activate inflammatory signalling pathways, which are mediated by their receptor for advanced glycation endproducts (RAGE). RAGE is the signal transduction receptor which distinguishes a variety of signalling molecules including AGEs, β-amyloid, HMGB1...
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Advanced glycation endproducts and their receptor (RAGE) in Alzheimer's disease
Štorkánová, Jesika ; Chlebek, Jakub (advisor) ; Opletal, Lubomír (referee)
Štorkánová, J.:Advanced glycation endproducts and their receptor RAGA IN Alzheimer's disease, Bachelor thesis, Charles University in Prague, Faculty of Pharmacy in Hradec Kralove, Department of Pharmaceutical Botany and Ecology, Hradec Kralove 2016, 97 p. Alzheimer's disease (AD) is the most common cause of dementia of late life. AD manifests as progressive memory impairment followed by a gradual decline in other cognitive abilities. For AD is characteristic the abnormal accumulation or aggregation of proteins. Advanced glycation endproducts (AGEs) are a heterogenous group of compounds that are formed when carbonyl group of reducing sugars reacts by a non-enzymatic reaction with amino acids in proteins, lipids and nucleic acids. The formation of AGEs promotes the deposition of proteins due to the protease resistant crosslinking, therefore is difficult to eliminace them from organism. AGEs can be detected in pathological deposits such as amyloid plaques and neurofibrillary tangles, which are prominent pathological feature sof AD. The formation of AGEs activate inflammatory signalling pathways, which are mediated by their receptor for advanced glycation endproducts (RAGE). RAGE is the signal transduction receptor which distinguishes a variety of signalling molecules including AGEs, β-amyloid, HMGB1...
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