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National Repository of Grey Literature 1 records found  Search took 0.00 seconds. 
Small fiber neuropathy in peripheral and autonomic nervous system in patients with diabetes
 Potočková, Veronika ; Mazanec, Radim (advisor) ; Voháňka, Stanislav (referee) ; Kunc, Pavel (referee)
Small fiber neuropathy in peripheral and autonomic nervous system in patients with diabetes Abstract This dissertation thesis wants to draw attention to the relevance of early detection of small nerve fibers damage in the somatic and autonomic nervous systems in patients with type 1 and type 2 diabetes mellitus (T1DM, T2DM). Only early diagnosis can prevent the severe complications that progressive forms of diabetic neuropathy (DN) bring. The main objectives of this work were to evaluate the possibility of using thermal quantitative sensory testing (TQST) to identify patients with diabetes at higher risk of cardiac autonomic neuropathy (CAN) and distal symmetric polyneuropathy (DSPN) with predominant small nerve fibers impairment. Other aims were to assess the impact of CAN on the development of carotid atherosclerosis and to determine the prevalence and risk factors for depression and anxiety in diabetic patients with and without DN. The results show that TQST can be used as a screening tool to identify patients with a higher risk of CAN. We demonstrated a significant effect of CAN presence on carotid intima-media thickness in patients with T1DM, independently of known risk factors of atherosclerosis. Such a finding suggests that CAN may play a role in the pathogenesis of carotid atherosclerosis. Another...
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