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The effect of opioids on the immune system
Miniariková, Nina ; Novotný, Jiří (advisor) ; Cimermanová, Veronika (referee)
The use of opioids in medicine is necessary as they serve to suppress pain as a part of anesthesia notably during surgical procedures. After that, they help suppress pain during postoperative care and they are also prescribed to patients with chronic pain, for example in the final stages of cancer. However, opioids are among the most abused substances worldwide. The United States of America is facing an opioid epidemic, also called the opioid crisis, which began mainly with the excessive prescription of opioids and their subsequent misuse. It is clear that opioids affect the immune system which has been the subject of many recent studies. Different opioids have variable effects on the immune system. The understanding of their impact on the immune system could mean improvement of health care, and at the same time could present a basis for proposals of new treatment methods for some of the diseases. This bachelor thesis summarizes the available studies dealing with the influence and effects of various opioids on the cells of the immune system in order to better understand their importance and their use in practice. Keywords: opioids, immune system, inhibition, immunomodulation, phagocytes, lymphocytes
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Anti-tumor activity of mesenchymal stem cells
Džuganová, Barbora ; Krulová, Magdaléna (advisor) ; Indrová, Marie (referee)
Mesenchymal stem cells (MSCs) are multipotent cells with the ability to migrate to inflammation sites and to tumor sites. They are able to regenerate the damaged tissues and also easy to isolate and cultivate. Furthermore, they can inhibit tumor cells and modulate the immune response. They are non-toxic in the organism and genetic modification of them can enhance their antitumor effect. MSCs can also serve as a vehicle for delivery of the therapeutic agent to the tumor. These properties make them special for anti-tumor therapy. Under some conditions, MSCs can also stimulate the tumor growth. This work discusses conditions in which MSCs inhibit the growth of cancer cells, as it is not yet clear on which precise mechanisms this inhibition is based.
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Anti-tumor activity of mesenchymal stem cells
Džuganová, Barbora ; Krulová, Magdaléna (advisor) ; Indrová, Marie (referee)
Mesenchymal stem cells (MSCs) are multipotent cells with the ability to migrate to inflammation sites and to tumor sites. They are able to regenerate the damaged tissues and also easy to isolate and cultivate. Furthermore, they can inhibit tumor cells and modulate the immune response. They are non-toxic in the organism and genetic modification of them can enhance their antitumor effect. MSCs can also serve as a vehicle for delivery of the therapeutic agent to the tumor. These properties make them special for anti-tumor therapy. Under some conditions, MSCs can also stimulate the tumor growth. This work discusses conditions in which MSCs inhibit the growth of cancer cells, as it is not yet clear on which precise mechanisms this inhibition is based.
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