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National Repository of Grey Literature 3 records found  Search took 0.01 seconds. 
Studium významu a mechanismů zapojení získané imunity při nádorové imunoterapii založené na synergii agonistů TLR a ligandů stimulujících fagocytózu
 VENHAUEROVÁ, Anna
This master thesis is focused on analysis of involvement of adaptive immunity during antitumour MBTA immunotherapy which is based on synergy of TLR agonist, anti-CD40 and phagocytosis stimulating ligands anchored into the tumour cells membrane. This immunotherapy was tested in murine pancreatic adenocarcinoma Panc02 model. The aims of this thesis were to analyse the tumor infiltration during therapy and examine the role of adaptive immunity using KO mice. Subsequently, the possibilities of strengthening immunotherapeutic effects using inhibitor of survivin YM155, betaglucans or anti-TGF in metastatic murine Panc02 model were tested.
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Cancer therapy based on the use of the anchored agonists of phagocytic receptors. The study of mechanisms using immunodeficient mice
 WALDMANNOVÁ, Eva
The aim of this thesis was to study the mechanisms of innate imunity involved in the degradation of tumor cells on which the ligands of phagocytic receptors were installed. For this purpose both in vivo experiments using immunodeficient mice, and in vitro experiments based on monitoring the levels of inflammatory cytokines produced in the tumor tissue and on measuring the level of myeloperoxidase released during neutrophil degranulation were performed.
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Development of protective immune response in gastric mucosa of mice infected with \kur{Cryptosporidium muris} and \kur{Cryptosporidium andersoni}
 JALOVECKÁ, Marie
The development of immune response accountable for the ability to control Cryptosporidium muris TS03 infection was studied using immunocompetent and various types of immunodeficient mouse models. Subsequently the immune response was characterized by analysis of leukocyte infiltration and cytokine production in gastric epithelium. Moreover, the potentiality of immunocompetent mice to develop effective immune response to C. andersoni LI03 infection with consequent protection to consequent infection of the same mice with C. muris TS03 was also studied by monitoring oocysts shedding, leukocyte infiltration of the gastric mucosa and cytokine production in ex vivo cultures of splenocytes.
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