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National Repository of Grey Literature 1 records found  Search took 0.01 seconds. 
Cortical microcircuits and synaptic transmission in epilepsy
 Doležal, Filip ; Králíková, Michaela (advisor) ; Svoboda, Jan (referee)
Epilepsy is a permanent predisposition of the brain to generate epileptic seizures. This widespread disease significantly impairs patients' life. Since epilepsy is defined only by its common symptoms, the research is complicated due to the variety of possible causes that can result in this disorder. Although many forms of therapy targeting different etiologies of this disorder exist, it is often challenging to select the right treatment and about one third of the patients still suffer from refractory seizures. Nevertheless, several proteins that participate in synaptic transmission and may undergo specific changes in their function have been identified. These changes in function affect both the activity of synapse and the involvement of synaptic connections in neuronal microcircuits. Microcircuits are common motifs of connections amidst excitatory and inhibitory neurons that are necessary for the transmission and processing of information in the brain. Microcircuits can be temporarily or permanently impaired by pathogenic processes on the molecular level, which may be responsible for the origination and propagation of seizures. Keywords epilepsy, ictogenesis, microcircuits, synaptic transmission
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