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National Repository of Grey Literature 2 records found  Search took 0.01 seconds. 
Energetic metabolism of heart during acut and chronic hypoxia
 Kolář, David ; Žurmanová, Jitka (advisor) ; Sotáková, Dita (referee)
The heart is a highly oxidative tissue, which far exceeds the oxygen consumption of neurons. The centre of ATP production is therefore in oxidative phosphorylation, which is contributed to by different substrates (glucose, fatty acids and lactate) depending on metabolic conditions. A high proportion of mitochondria in heart tissue carries an increased risk of reactive oxygen species development in the possible disruption of mitochondrial metabolism. Oxygen radicals are generated primarily at complex I and III of the respiratory chain of mitochondria. They may perform a signalling role allowing the heart adaptation to hypoxia, but the high concentration leads to irreversible damage /of cellular structures. This thesis considers the energy metabolism of the heart under normoxic, hypoxic and ischemic conditions, with emphasis on the glucose and fatty acids uptake, and the control of oxidative phosphorylation.
Detailed record
Energetic metabolism of heart during acut and chronic hypoxia
 Kolář, David ; Žurmanová, Jitka (advisor) ; Sotáková, Dita (referee)
The heart is a highly oxidative tissue, which far exceeds the oxygen consumption of neurons. The centre of ATP production is therefore in oxidative phosphorylation, which is contributed to by different substrates (glucose, fatty acids and lactate) depending on metabolic conditions. A high proportion of mitochondria in heart tissue carries an increased risk of reactive oxygen species development in the possible disruption of mitochondrial metabolism. Oxygen radicals are generated primarily at complex I and III of the respiratory chain of mitochondria. They may perform a signalling role allowing the heart adaptation to hypoxia, but the high concentration leads to irreversible damage /of cellular structures. This thesis considers the energy metabolism of the heart under normoxic, hypoxic and ischemic conditions, with emphasis on the glucose and fatty acids uptake, and the control of oxidative phosphorylation.
Detailed record

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