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Hyperkoagulační stavy v graviditě a jejich komplikace
KABELOVÁ, Kristýna
Hypercoagulable states occur when the process of hemostasis is disturbed. It manifests as a deep vein thrombosis or a pulmonary embolism. It is also one of the most common cardiovascular diseases. There are two factors- genetic and acquired. Inherent factors involve coagulation inhibitor deficiency, prothrombin gene mutation and activated protein C resistance. Acquired factors include antiphospolipid syndrome, pregnancy, overweight etc. The analytic part of the thesis is focused on the effect of a low molecular weight heparin. It was shown in many theses that the LMWH could have a negative impact on a parturition complications or a week of parturition, a birth weight. The results of statistical analysis show that there is a coherence between the week of parturition and the type of parturition. What is more, the anticoagulation drug therapy shows a positive effect on the week of parturion. The data used in the thesis originate in laboratory information management system of Clinical Haematology ward in the hospital Nemocnice České Budějovice a.s.
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Vztah Leidenské mutace a rezistence na aktivovaný protein C
ZEMANOVÁ, Vendula
This thesis was about the relationship of the Factor V Leiden mutation and activated protein C resistance. I looked up patients with Leiden mutation and activated protein C resistance. I monitored the frequency of thromboembolism and miscarriages in the personal and family case history of patients. Subsequently, I looked up if other risk factors which affect clinical manifestations in patients with this mutation can be found.
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Rizika tromboembolického onemocnění u žen
BÁRTOVÁ, Marie
Thromboembolic disease is one of the most common cardiovascular diseases which includes deep vein thrombosis and pulmonary embolism. It is affected by genetic and acquired factors. The major risks of thromboembolic disease for women include inherited hypercoagulable states, pregnancy, repeated abortions or using hormonal contraception. The first part of the thesis is focused on prevalence of thrombophilic states mutation FV Leiden and mutation G20210A prothrombin among women patients in hospital in České Budějovice a.s. in 2015. The second part of the thesis is focused on the knowledge of the risks of the thromboembolic disease among the women who use or used hormonal contraceptive.
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Thromboembolic disease in pregnancy
ŠOTOVÁ, Karolína
This thesis was about thrombomebolic disease in pregnancy. The incidence of venous thromboembolism (VTE) probably increases 2- to 4-fold when a woman becomes pregnant. I looked on this problem from many aspects. I looked on health care from her gynaecologist and eventually hematologist, recognition her VTE risk, laboratory tests and her medication. I looked on effectivity of medication too.
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