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National Repository of Grey Literature 2 records found  Search took 0.01 seconds. 
Interaction of cidofovir and brincidofovir with human skin in vitro
 Vencovská, Lenka ; Vávrová, Kateřina (advisor) ; Kováčik, Andrej (referee)
Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department of organic and bioorganic chemistry Lenka Vencovská Supervisor: prof. PharmDr. Kateřina Vávrová, Ph.D. Title of diploma thesis: Interaction of cidofovir and brincidofovir with human skin in vitro Brincidofovir (BCDV) is a broad spectrum antiviral drug used for the treatment of various viral infections. This prodrug is after targeting the site converted to cidofovir (CDV), whose topical activity has been studied. The application of drugs into or through the skin has a number of advantages over conventional routes of administration. The disadvantage of this type of administration is the inability of drugs to penetrate through the skin in sufficient quantities. To improve skin permeation, we use substances calles transdermal permeation enhancers. 6-dimethylaminohexanoic acid dodecyl ester (DDAK) was used for this study. In my thesis, I have studied the penetration of BCDV into isolated human skin, the effect of the addition of transdermal permeation enhancer on this permeation and the changes that the drug may exert on the skin barrier. The changes in the skin barrier have been studied by infrared spectroscopy, electrical impedance and water loss through the skin. The results of the study show that the amount of drug...
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Procedural generation of human skin structure
 Čermák, Jan ; Křivánek, Jaroslav (advisor) ; Beneš, Jan (referee)
Title: Procedural generation of human skin structure Author: Jan Čermák Department: Department of Software and Computer Science Education Supervisor: doc. Ing. Jaroslav Křivánek, Ph.D. Abstract: Human skin is a very complex and diverse organ that differs not on- ly among different people and races, but also in the scope of one specific human body. In this thesis we tested several procedural approaches to generate textu- re suitable for surfaces of 3D models of various parts of human skin. Besides cellular structures using Voronoi diagrams or Delaunay triangulation, we also in- vestigate generation of the structure of human fingerprints based on the SFinGe method, used for creating synthetic fingerprints for fingerprint recognition algo- rithms in criminology. We conclude that human skin is so diverse that multiple different approaches are needed and each of them is suitable only for some regions. Keywords: computer graphics, procedural modeling, human skin 1
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