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National Repository of Grey Literature 2 records found  Search took 0.01 seconds. 
Numerická simulace účinků léčiv na srdeční akční potenciál
 Převorovská, Světlana ; Maršík, František
The aim of the paper is a numerical simulation of the antiarrhythmic drugs effects on the cardiac action potential realized by the numerical model of the human cardiovascular system. The pulsating blood flow of the cardiovascular system is generated by the electrochemical and mechanical activity of heart muscle. This system is being modelled by four segments of the pulsating heart and by twenty three vascular segments of pulmonary and systemic circuits connected with the heart segments in series. The behaviour of the cardiovascular system is described by the heart rate and by its hemodynamical variables, i.e. the blood pressure, volume, flow, by the cardiovascular parameters such as the blood inertia, compliances and resistances in corresponding segments and by the physicochemical variables such as the cardiac action potential, the calcium, sodium and potassium ionts concentration.
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The influence of the membrane transport on the heart mechanical activity
 Převorovská, Světlana ; Maršík, František
The mechanical activity of the heart muscle is the response of the electrochemical processes at the myocardial cells level. The influence of the sodium, potassium and calcium ions transport through the myocyte cells membrane and the generation of the myocardial action potential on heart mechanical activity has been simulated by the numerical model.
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