National Repository of Grey Literature 1 records found  Search took 0.01 seconds. 
Reflexive measurement of thermal hyperalgesia in neuropathic pain model
Panušková, Kristýna ; Vaculín, Šimon (advisor) ; Adámek, Pavel (referee)
Neuropathic pain substantially decreases a person's quality of life and thus far nothing has been invented that can alleviate that pain. One of the most commonly used model for induced peripheral neuropathic pain in animals is chronic constriction of the sciatic nerve. Experimental induction of neuropathic pain in rats is verified by reflexive measurement. Reflexive measuring can also be used to test the efficacy of the experimental treatment. The large range of reflexive tests that can be applied differ in terms of the stimulus used and the area of stimulation. This bachelor thesis will focus on analyses of the thermal pain threshold after a chronic constriction injury (CCI) to the sciatic nerve. Articles used in this thesis were found in the electronic database PUBMED/MEDLINE by searching for the terms "chronic constriction injury" and "pain threshold" for last 10 years. Articles related to the thermal pain threshold of rats after CCI were ranked according to the prestige of magazine that published them and ten articles with a quartile of 1 were selected for further analyses. The tests used, control methods during the study, measuring interval, measurement before operation and pain threshold values were extracted from these articles. Measurement of behavioral signs is not unified. The Hargreaves...

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