|
|
Analýza výskytu vybrané dědičné choroby očí u psů
KUBIČKOVÁ, Miroslava
Progressive rod-cone degeneration (PRCD) is the late form of progressive retinal atrophy (PRA). It is an autosomal recessive hereditary retinal defect. This disease in dogs is consistent with one form of retinitis pigmentosa (RP) in humans. Phenotypic manifestations are identical and it is known to be an identical causal mutation. A study of this defect in dogs could also explain a lot in human medicine. The gene for PRCD was mapped in the region of centromer of the canine chromosome 9 (CFA9). In this thesis, genotyping of 120 dogs of different breeds and age was performed. Most represented a breed of English Cocker Spaniel which is predisposed to the disease. Analysis PRA-PRCD was performed by molecular genetic methods PCR-RFLP and the horizontal agarose electrophoresis. Genotypes were determined on the basis of different fragment lengths. The normal allele was 396 bp in length and the mutated allele had a length of 116 bp. Presence of mutated allele was only detected in 25 heterozygotes carriers which were usually breeds with this predisposition. Frequency of the mutated allele was 10.4 %. In the selected population 20.8 % of heterozygotes were represented. The results of the study show approximately one fifth of the tested dogs are heterozygous carriers. Findings of other studies confirm there are generally more heterozygotes than homozygotes in which the disease is manifested during life. However, if this fact is not clearly taken in consideration, the number of sick dogs can rapidly increase during short period of time. In the future, it would be appropriate to adopt measures which would definitely eliminate the occurrence of the mutated allele. These measures could include genetic tests that reliably reveal hidden carriers (heterozygotes) in predisposing breeds. Heterozygotes may increase the representation of this allele in the population. This leads to an increase in the number of diseased animals.
|
|
|
Dědičné choroby psů vázané na pohlavní chromozomy
ČÍŽKOVÁ, Pavla
The thesis sumps up the most important and the most often diseases linked to sex chromosomes. The beginning of the work describes genetic information of dogs also mutations connected to genetic diseases and distribution of the genetic illnesses itself. The thesis follows with heredity of characters connected with sex and the origin of X and Y chromosom. The last part of the thesis describs the illnesses, symptoms, genetic backround, diagnostics and treatment.
|
|
|
Nejzávažnější dědičné choroby u labradorských retrieverů
STARÁ, Martina
This thesis represents a review of most serious hereditary diseases in Labrador Retriever. Clinical symptoms, genetic background, diagnosis and treatment of variol diseases are described. The terms cocluded to hereditary diseases are explained. In conlusion, some recommendation for breeders are mentioned.
|
|
|
The genetic background of the selected hereditary disease in dogs
KUBIČKOVÁ, Miroslava
The bachelor thesis is focused on hereditary hernia in dogs. It constitutes of a summary literature review of the most frequently occurring types of hernia. For comparison, there are included non-hereditary hernias. The thesis describes prevalence, clinical symptoms, methods of diagnosis and treatment. The work mentions the genetic basis of the disease, including the method of transmission to the next generation and the estimated heritability. It explains the notions that relate to this topic. At the end of thesis, there are formulated practical advice for breeders.
|
|
|
Inherited skin diseases by dogs
BEEROVÁ, Michaela
The bachelor thesis is focused on hereditary skin disease of dogs. Constitutes of a summary of the most common and important hereditary disease. It describes the clinical signs, diagnosis and treatment. It mentions transmission method to the next generation. Explains the terms which are relate to hereditary disease. At the end of thesis are mentioned an advice for breeders.
|
guest ::
