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National Repository of Grey Literature 2 records found  Search took 0.01 seconds. 
Genetická diverzita potenciálně terapeutické tasemnice Hymenolepis diminuta (Cestoda: Cyclophyllidea)
 ŘEŽÁBKOVÁ, Lucie
The tapeworm Hymenolepis diminuta is highly prevalent in rat populations and has also been observed rarely in humans. H. diminuta has become a leading candidate for helminth therapy used to treat or prevent inflammatory diseases of humans in Western society. While most of the experimental isolates of H. diminuta are identified based on typical morphological features, hymenolepidid tapeworms may represent complexes of cryptic species as detected by molecular sequence data. In the present study, we explored the diversity of laboratory-kept strains using partial sequences of two genes (lsrDNA and cox1) and determined that H. diminuta isolates currently considered for therapeutic purposes in the US and Europe belong to a single, genetically nearly uniform lineage, showing only little genetic deviation from wild isolates.
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Sledování imunomodulačních účinků extraktů z helminta na makrofágové buněčné kultuře
 ŘEŽÁBKOVÁ, Lucie
The main aim of the present study was to determine the immunomodulatory effects of extracts obtained from the commensal helminth, Hymenolepis diminuta, on in vitro rat macrophages. Here, I tested two types of crude extracts derived from various tapeworm's life stages (larval stages, adults) and excretory/secretory products (ES-products). The in vitro inflammatory model was induced by bacterial lipopolysaccharides (LPS) to compare the results with normal state of macrophages. To monitoring immune response, I analysed the relative gene expressions of several cytokines TNF, IL-10, IL-1; signal transducer and activator of transcription STAT6 as well as IL-17re using by qPCR. The presence of adult extracts caused no obvious immune response of macrophages. The larval extract and ES-products induced an inflammatory response. All three types of compounds derived from H. diminuta reduced the inflammation of macrophages influenced by LPS.
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