|
|
Rhythmic function of placenta and the impact of disruption in maternal-placental-fetal axis
Světlíková, Nela ; Sumová, Alena (advisor) ; Pačesová, Dominika (referee)
In mammals, the circadian rhythms result of a complex endogenous system consisting of hierarchically organized oscillators. The system enables the synchronization of the organism's internal processes with the external environment. It consists of the main component, the central clock, located in the suprachiasmatic nuclei in the hypothalamus, and peripheral clocks in other cells, tissues and organs. The placenta is a temporary, specialized mammalian organ that is part of the mother-placenta-fetus axis and exhibits rhythmicity in its functions. The aim of this thesis is to summarize the rhythmic functions of the placenta, such as immunity, protection, and production of hormones and other mediators that play an important role in fetal development and pregnancy. In addition, the thesis also describes rhythmic changes, that occur during pregnancy in the mother-placenta-fetus axis and how these rhythms influence each other. Keywords Placenta, circadian clock, ontogenesis, fetus, maternal synchronization, hormones, enzymes, immunity
|
guest ::
