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National Repository of Grey Literature 1 records found  Search took 0.00 seconds. 
The role of extracellular vesicles in transmission of dsRNA viruses in parasitic protist Trichomomas vaginalis.
 Horáčková, Jana ; Rada, Petr (advisor) ; Voleman, Luboš (referee)
Trichomonas vaginalis is a parasitic protist found in the human urogenital tract, where it adheres to the epithelial cells. During infection, T. vaginalis cells release extracellular vesicles that allow them to communicate with each other and modulate the host immune response. Most studied T. vaginalis strains contain dsRNA Trichomonasviruses (TVVs). These viruses belong to the Totiviridae family, which includes other dsRNA viruses from various parasitic protists. TVV is transmitted vertically to the daughter cells during cell division. Horizontal transfer of TVV between T. vaginalis cells has not yet been proven. TVV particles were found inside small extracellular vesicles that release infected T. vaginalis into the extracellular space. In this thesis, it was shown that TVV could be transmitted between trichomonads during co-cultivation of infected and uninfected trichomonads. However, stable TVV infection of trichomonads was not observed. It was also proven that extracellular vesicles from infected trichomonads could transmit TVV among other trichomonads. Nevertheless, this way of transmission did not lead to the stable TVV infection of trichomonads either.
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