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National Repository of Grey Literature 3 records found  Search took 0.01 seconds. 
Idea design of experimental model for LV electric arc properties investigation
 Fazekas, Tibor ; Valenta, Jiří (referee) ; Vávra, Zdeněk (advisor)
The aim of the work was a planing of an experimental model for the observation of the low voltage electric arc. The opening part observes the basics of the electric network switching and the electric arc in theory. The next point is definition about the behaviour of the electric arc in the low voltage switching devices, focusing on the movement of the arc along electrodes and in the extinguish chamber. The design of the experimental model, created in Autodesk Inventor 2008, is described in the last part of the work.
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Effect of combined endothelin and renin-angiotensin systems blockade on blood pressure and chronic kidney disease regression in model of angiotensin II-dependent hypertension
 Sedláková, Lenka ; Kopkan, Libor (advisor) ; Bürgelová, Marcela (referee)
and key words Enhanced activation of renin-angiotensin system (RAS) and endothelin system (ES) plays the key pathophysiological role in the progression of hypertension and the chronic kidney disease (CKD). The aim of this study was to verify wheter the combined inhibition RAS and selective inhibition ETA receptor for endothelin 1 (ET-1) will show additive renoprotective effects in experimental model CKD. This therapeutic aproach was tested on the transgenic rats with mouse renin gen (TGR), to whome ablation nephrectomy (5/6 NX) was done in the age of 6 weeks. After next 6 weeks the relevant treatment was given in drinking-water: dual RAS blockade (trandolapril 6mg/L + losartan 100mg/L) or the combination of dual RAS blockade + inhibitor of ETA receptor (atrasentan 25mg/L). Results of the first series show 100 % mortality in untreated rats with 5/6 NX to the 30th week. Both type of treatments increased the survival rate up to 30 % in 5/6 NX TGR after the 50th week. In the second series influence of treatments on the blood pressure (BP) was monitored in 5/6 NX TGR, which had systolic BP over 210 mmHg. Both treatments decreased BP to the level normotensive rats and reduced heart hypertrophy. In the third series the results showed that treatment significantly decreased renal level of angiotensin II...
Detailed record
Idea design of experimental model for LV electric arc properties investigation
 Fazekas, Tibor ; Valenta, Jiří (referee) ; Vávra, Zdeněk (advisor)
The aim of the work was a planing of an experimental model for the observation of the low voltage electric arc. The opening part observes the basics of the electric network switching and the electric arc in theory. The next point is definition about the behaviour of the electric arc in the low voltage switching devices, focusing on the movement of the arc along electrodes and in the extinguish chamber. The design of the experimental model, created in Autodesk Inventor 2008, is described in the last part of the work.
Detailed record

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