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National Repository of Grey Literature 2 records found  Search took 0.01 seconds. 
Prediction of the Effect of Amino Acid Substitutions on Secondary Structure of Proteins
 Hyrš, Martin ; Vogel, Ivan (referee) ; Bendl, Jaroslav (advisor)
In this thesis I investigate the effect of amino acid substitutions on secondary structure of proteins. I found that the secondary structure is relatively resistant to mutations, some regions hold the same secondary structure, even though their sequences are very different. Since this effect was observed also for random sequences, I conclude that it is a general property of the amino acid sequence. The particular elements of secondary structures are differentially sensitive to the changes caused by mutations. Protein's sensitivity to mutations depends on the composition of its secondary structure. Some methods of secondary structure prediction are described in the introductory section.
Detailed record
Prediction of the Effect of Amino Acid Substitutions on Secondary Structure of Proteins
 Hyrš, Martin ; Vogel, Ivan (referee) ; Bendl, Jaroslav (advisor)
In this thesis I investigate the effect of amino acid substitutions on secondary structure of proteins. I found that the secondary structure is relatively resistant to mutations, some regions hold the same secondary structure, even though their sequences are very different. Since this effect was observed also for random sequences, I conclude that it is a general property of the amino acid sequence. The particular elements of secondary structures are differentially sensitive to the changes caused by mutations. Protein's sensitivity to mutations depends on the composition of its secondary structure. Some methods of secondary structure prediction are described in the introductory section.
Detailed record

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