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Hormonally active substances in the aquatic environment and risk to aquatic organisms and human.
Duisembay, Zhuldyz ; Bušová, Milena (advisor) ; Ezechiáš, Martin (referee)
This bachelor thesis aims to investigate the presence, sources and impacts of hormonally active substances, or endocrine disruptors (EDs), in the aquatic environment. These substances, including long-lived persistent organic pollutants (POPs), e. g. pesticides and polycyclic aromatic hydrocarbons (PAHs), and non-persistent pollutants such as bisphenol A and alkyphenols, directly or indirectly affect the hormonal systems of aquatic organisms and humans. For instance, it was observed, that elevated concentrations of certain progestogens impact fertility, reproductive processes, induce transcriptional changes, and alter sex ratios within fish populations. Numerous studies in the field focus on evaluating the manifestation of EDs in water, their effects on behavior and vital functions of aquatic organisms and humans, and the challenges associated with their detection and removal from the wastewater discharged into the environment. Recent researches have revealed elevated concentrations of specific EDs in various regions, including Czech Republic (significant concentrations of levonorgestrel, megestrol acetate (MGA), drospirenone and dienogest were detected in Blanice river). This indicates a lack of regulations and potential difficulties in effectively removing these substances from water with...
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Sperm maturation process in fishes (review)
KŘIŠŤAN, Jakub
The main aim of this thesis was to review the current knowledge in the field of fish sperm maturation (a process where immature spermatozoa acquire the potential to respond to motility-activating factors) and the urogenital system structure in relation to this maturation.
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Mechanisms of potential toxic effects of bisphenol A on the endocrine system
Zachardová, Lenka ; Novotný, Jiří (advisor) ; Rupert, Marian (referee)
Bisphenol A (BPA) has already been used in the chemical industry for several decades. Since that time, a huge amount of in vitro and in vivo studies have been accumulated summarizing the molecular mechanisms of BPA causing disruption in endocrine homeostasis in all kinds of biological models. It enters the body from external environment; however, the main source of penetration is through consumption of food and liquids that are in contact with materials containing the mentioned xenoestrogen. The hydroxyl group within BPA phenol ring enables binding to transmembrane G- protein-coupled estrogen receptors and a number of nuclear receptors affecting hormonal system and resulting in alterations in signalling pathways. BPA induces oxidative stress and interferes with regulation factors functions at gene, cell and tissue level. Disruptive effects are associated with developmental, reproductive, cardiovascular, immune and neurobiological disorders. This thesis is aiming to sum up existing findings about the molecular mechanisms of BPA toxicity in the endocrine system mainly using Mus musculus model. Keywords: BPA, endocrine system, nuclear receptors, GPER, oxidative stress.
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Reakce neuroendokrinního systému koní na stres
Šimková, Daria
ŠIMKOVÁ, D. Reaction of Horse´s Neuroendocrine System to Stress. Mendel University in Brno, 2017. Bachelor thesis. The bachelor thesis deals with the issue of stress in connection with neuroendocrine systems. The work is focused on the comparison and cooperation of these two systems depending on the stress. The first part describes general characteristics of the endocrine system and hormones, a general description of the nervous system and the definition and view of stress. In the next part are given the specific organs of the given systems and their main function. End of the chapter is devoted to the pathological processes of both systems. In conclusion the effect of stress on these systems and the impact on possible desorders and diseases of the neuroendocrine system are summarized.
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Hormonal changes in strength training
Rafael, Gáll ; Petr, Miroslav (advisor) ; Šteffl, Michal (referee)
Title: Hormonal changes in strength training Objectives: Perform a systematic review of literature dealing with hormonal changes in strength training. Based on the informations from aforementioned literature, describe wheather acute hormonal response after a bout of strength training significantly influence the proces of hypertrophy or not. Hormone testosterone and changes of its concentrations is for this thesis the most important. Methods: Method of traditional review was used in this thesis. Results: The presence of acute hormonal changes occurred in strength training was confirmed in numerous studies. Role of this hormonal response is because of variability in results not very clear yet. Chronicle changes of resting hormonal levels in strength training are not observed according to results of studies. For better understanding of hormonal strength in strength training, another studies have to be executed. Keywords: endocrinal system, strength training, hormonal response, testosterone, hypertrophy.
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