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Possibilities of influence of cardiovascular risk markers with a diet enriched with amaranth flour
Chmelík, Zdeněk ; Vrablík, Michal (advisor) ; Piťha, Jan (referee) ; Vohnout, Branislav (referee)
Univerzita Karlova v Praze 1. lékařská fakulta Abstrakt dizertační práce Možnosti ovlivnění markerů kardiovaskulárního rizika stravou obohacenou amarantovou moukou PharmDr. Zdeněk Chmelík Praha 2022 Abstract (EN) Introduction: Diet suitable for lipid metabolism disorders should not increase the total and LDL cholesterol, and ideally should assist in its lowering. Analysis of literary sources suggest that amaranth can meet these properties. Aim: The execution of literary investigation of the issue and experimental verification of lipid- lowering effect of amaranth flour in laboratory conditions. Methods: 50 (Experiment 1) or 40 (Experiment 2) The mice were divided into five (Experiment 1) or four (Experiment 2) groups fed by control mixture (C), high-energy diet (HED), high- energy diet with amaranth (HED+A) and in Experiment 1, by high-energy diet with amaranth flour and simvastatin (HED+A+S) or only with simvastatin (HED+S), and in Experiment 2 a by high-energy diet with squalene (HED+S). Weight gains were measured and TC, LDL and HDL cholesterol determined. Results: Feeding of HED diets resulted in a statistically significant increase in the TC cholesterol by 81% (Experiment 1) or 125% (Experiment 2), LDL cholesterol of 612% (Experiment 1) or 304% (Experiment 2) and a decrease in HDL cholesterol by 8.4%...
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Cholesterol and Lipoproteins, Their Metabolism and Effect on Human Health
Záhořová, Karolína ; Pavlasová, Lenka (advisor) ; Ehler, Edvard (referee)
Cholesterol and lipoproteins, their impact (aspect) on human health The thesis is focused on cholesterol, lipoproteins and their metabolism. Detail is devoted to their charakteristics, significance, function in the body and the effects on human health. The first chapter summarizes informations about cholesterol chemical properties and structure, through its processing to the characteristic, importance and function in the human body. There are analyzed opportunities to affect cholesterol levels. The second chapter presents lipoproteins as particles for our body essential. It includes their characteristic, classification, meaning and function in the body. The third chapter provides information about dyslipidemia. It focuses on the classification, significance and treatment. The following chapter deals with atherosclerosis, its causes, consequences and risks. A recent chapter presents a brief overview from part of laboratory analyzes on lipid and lipoproteins. Key words: Cholesterol, lipoprotein, dyslipidemia, hyperlipoproteinemia, atherosclerosis.
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Influence of Diet on Blood Lipid Levels in Dyslipidemic Patients
Paroha, Josef ; Zlatohlávek, Lukáš (advisor) ; Tůmová, Eva (referee)
The primary aim of this thesis is to determine whether the hypolipidemic diet has an influence on blood lipid levels in patients with dyslipidemia. The secondary aim is to find out the eating habits of patients with dyslipidemia and to determine whether their eating habits are in line with the basics of a hypolipidemic diet. To achieve these targets a questionnaire, biochemical examination of blood and education of dyslipidemic patients on the appropriate diet were used. My research contained check-in and check-out laboratory blood examinations. After check-in examination each patient filled in the questionnaire with questions targeted at eating habits and then the patient was educated about the appropriate diet. After three months' time the patients proceeded to check-out laboratory blood examination. The necessary data were acquired by comparing the results of the check-in and check-out blood examinations and by the questionnaires evaluation. This thesis in its research confirmed the positive influence of hypolipidemic diet on blood lipids levels in patients with dyslipidemia. At the end of the research the average level of total cholesterol was 10,5 % lower, the average level of LDL-cholesterol was 18,9 % lower and the average level of triacylglycerol was 10,6 % lower. On the contrary the...
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Effect of education on blood lipid levels in patients with dyslipidemia
Lorencová, Marie ; Zlatohlávek, Lukáš (advisor) ; Tůmová, Eva (referee)
V této bakalářské práci se zabývám vlivem dietních a režimových opatření učiněných při léčbě dyslipidemie coby nejvýznamnějšího faktoru aterosklerózy. U souboru edukovaných pacientů byl sledován efekt edukace na jejich laboratorní hodnoty, resp. zlepšení zdravotního stavu. V teoretické části předkládám základní přehled členění lipidů z chemického hlediska, pohled na současné informace o dyslipidemii a ateroskleróze, především na faktory ovlivňující tato onemocnění, a nakonec se věnuji zdravotnické edukaci a její důležité roli při edukaci pacientů. V kapitole Dieta při dyslipoproteinémii komplexně pohlížím na současná doporučení týkající se stravování, dále sleduji doporučovaná režimová opatření týkající se pohybu a zanechání kouření tabáku. Praktická část této práce je věnována sledování souboru pacientů, kteří byli edukováni a následně po edukaci mají dodržovat dietní a režimová opatření. V důsledku uzavření pracoviště z důvodu koronavirové epidemie jsem však musela svoji práci s pacienty předčasně ukončit a nezískala jsem tak potřebné podklady pro zpracování a následné vyvození závěrů. Proto jsem následně propracovala více teoretickou část této bakalářské práce a připojila jsem edukační materiál (letáky) pro pacienty s dyslipidemií. Klíčová slova dyslipidemie, ateroskleróza, dietní a režimová...
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Influence of education on blood lipid levels in dyslipidemic patients
Macinauerová, Romana ; Zlatohlávek, Lukáš (advisor) ; Šatný, Martin (referee)
Dyslipidemia belongs to the risk factors of cardiovascular diseases with the prevention and treatment based on the necessary dietary restrictions and a change in the lifestyle. The main aim of this work is to assess the impact of dietary restrictions and a healthier lifestyle on the patient's lipid profile, a secondary aim is to evaluate the patient's eating habits. The thesis is divided into two parts, a theoretical background and an applied study. The theoretical background describes the importance and types of different lipids in humans and their characteristic transport pattern and digestion. This work also explains the concept of dyslipidemia, the classification, treatment and diagnostic approaches and the role in a metabolic syndrome clustering. An important part of the dyslipidemia treatment and prevention is the public education and this part of the thesis also outlines different forms with the correct principles. An integral part of the education is the adherence of a patient, what may be a key aspect of the dyslipidemia treatment. The applied study exploits: (i) a questionnaire that follows eating habits and consummation frequency of selected foods and drinks in patients from the Lipid Clinic of The Center for Cardiovascular Prevention, General University Hospital in Prague and 1st...
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Importance of diet in influencing the risk factors of CVD in patients treated with statins
Bártová, Kateřina ; Vrablík, Michal (advisor) ; Vaclová, Martina (referee)
Diet and other regimens are part of the treatment of dyslipidemia, where the objective is trough modification lipid and lipoprotein metabolism, to influence the cardiovascular risk and to reduce the risk of atherothrombotic compliations. The aim of this work was to investigate the importance of different diets in influencing the risk factors of KVO in patients treated with statins, i.e. to assess the dietary habits of these patients by means of a questionnaire and to monitor the changes, from before to after, of the selected anthropometric and laboratoty parameters. The study included 41 patients of an average age of age of 50 years ± 11. The duration of statin therapy: 88 % of them over half year, 12 % of them less than six months. 73 % of them do not smoke, 27 % were smokers. The dietary habits questionnaire was completed by the patient prior to education and subsequently evaluated. The monitored parameters - weight, waist circumference, blood pressure, total cholesterol, HDL-c, non- HDL-c, LDL-c, triglycerides, glycemia, glycated hemoglobin in diabetics were evaluated before and after 2-3 months of education. Patients were predominantly familiar with the basic rules of a low fat diet but over 30% patients consume food inappropriately for the diet and over 30 % of patients did not consume foods...
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Education effect on blood lipid levels in patients with dyslipidaemia
Kuncířová, Veronika ; Zlatohlávek, Lukáš (advisor) ; Tůmová, Eva (referee)
The bachelor thesis examines the influence of education and diet on patients with dyslipidemia. Another object was to explore the eating habits of patients and find out if they are interested in a healthy lifestyle. The theoretical part is based on knowledge from the academic literature. It explains the concept of dyslipidemia, its divisions and causes of disease and describes possible methods of treatment. The pieces of information for the practical part are obtained through questionnaires from patients who are treated in the Center for Preventive Cardiology, 3rd Department of Internal Medicine, 1st Medical Faculty of Charles University in Prague. Another source are laboratory tests of blood, which were taken before education and then again after a minimum interval of one month from the education. Values were processed by using graphs and tables. The results clearly showed us that after education and compliance with the recommended diet, values of blood lipids were improved. On three of the four monitored lipid parameters diet had a positive impact. Furthermore, it appears that the majority of patients with dyslipidemia has good eating habits. The last point that has been studied, was the patients' interest in a healthy lifestyle. It revealed insufficinet interest at the majority of the...
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