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National Repository of Grey Literature 2 records found  Search took 0.00 seconds. 
Enantioselective allylation of thiophene-2-carbaldehyde
 Motloch, Petr ; Kotora, Martin (advisor) ; Veselý, Jan (referee)
The first part of the bachelor thesis deals with enantioselective allylation of thiophene-2- carbaldehyde to the corresponding chiral homoallylic alcohol by using chiral Lewis bases as catalysts. The highest asymmetric induction achieved was 97 % ee. The second part concerns application of the prepared chiral homoallylic alcohol as the crucial intermediate for synthesis of antidepressant (S)-duloxetine. Key words enantioselective, allylation, Lewis base, thiophene-2-carbaldehyde, duloxetine
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Enantioselective allylation of thiophene-2-carbaldehyde
 Motloch, Petr ; Kotora, Martin (advisor) ; Veselý, Jan (referee)
The first part of the bachelor thesis deals with enantioselective allylation of thiophene-2- carbaldehyde to the corresponding chiral homoallylic alcohol by using chiral Lewis bases as catalysts. The highest asymmetric induction achieved was 97 % ee. The second part concerns application of the prepared chiral homoallylic alcohol as the crucial intermediate for synthesis of antidepressant (S)-duloxetine. Key words enantioselective, allylation, Lewis base, thiophene-2-carbaldehyde, duloxetine
Detailed record

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