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The cellular elements participating in the inflammatory response
CHMELOVÁ, Veronika
The issue of inflammation is a very complicated and extensive topic, which by far does not just cells that the task of this thesis. It's a proces to helping maintain the internal environment of the organism and its task is cope with external environmental influences, which may mean risk for the organism. Inflammatory cell response is the mechanism which the body defends itself against infections and corrects damaged tissue. But this process can not be understood only as a defensive reaction. Especially with persistent inflammation may evolve a disease state which leads to irreversible tissue damage. In this case, the pathologic response. The theoretical part describes the course of inflammatory reactions and focus on individual blood cells. In this part of thesis, describe their morphological structure, interaction and role in the pathophysiological process. The practical part is devoted to specifics methods which can be used to investigate inflammatory cells. I appreciate their advantages and disadvantages, and describe the principles and practices of these methods. The most basic method is the fabrication and painting the blood smear and microscopic minus differential leukocyte budget. For higher level can be considered Hematology Analyzer, in addition to white blood cells provides a range of information, including platelets and red series. The last method, which the work is concerned with flow cytometry. The huge growth in recent years, the opportunity to investigate a large number of parameters. But this places high demands on the correct interpretation of the data. The last part is concerned with mast cell and problems of its investigations both in terms of hematological and histological methods.
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