|
|
Diagnostics of pathological changes in vascular system and innovative methods of interventional therapy
Novák, Matěj ; Lambert, Lukáš (advisor) ; Křivánek, Jiří (referee) ; Cihlář, Filip (referee)
Purpose. The objective of the first study was to compare the results of primary patency of failing dialysis arterio-venous fistulas and grafts when using drug-coated balloon catheters in comparison with simple balloon catheters. The aim of the second study was to quantify perfusion changes on CT pulmonary angiography (CTPA) in patients with chronic thromboembolic pulmonary hypertension (CTEPH). Methods. In the first study, a total of 76 patients were randomized to the study - 38 patients were treated with percutaneous transluminal angioplasty using a drug-coated balloon catheter, and 38 patients were treated with percutaneous transluminal angioplasty using a simple balloon catheter. Follow-up DSAs were performed at 3, 6, 9, and 12 months after baseline intervention. In the second study, CTPA in 58 patients with CTEPH were evaluated. The volume of the hypoperfused part of the lungs was measured using density thresholding in semi-automatically segmented lung volume and compared with hemodynamic parameters from catheterization. Results. In the first study, the primary patency in the PTA group with a drug-coated balloon catheter versus the PTA group with a simple balloon catheter was 86.7 ± 5.6% vs. 74.2 ± 7.4% at 3 months, 52.8 ± 8.4% vs. 25.6 ± 7.9% at 6 months, 21.8 ± 8.1% vs. 11.0 ± 5.9% at 9...
|
guest ::
