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Depressive rumination: testing the analytical rumination hypothesis in patients with depressive disorder
Janíčková, Petra ; Preiss, Marek (advisor) ; Dymešová, Gabriela (referee)
Depression is commonly viewed as a pathology. Depressive rumination, one of the key symptoms of depression is thought to be a maladaptive cognitive style that contributes to worse and longer depressive episodes. Here I present an alternative approach called the analytical rumination hypothesis (ARH). ARH proposes that depression is an evolved response to complex analytical problems. In a study on inmate patients of the National institute of mental health in Klecany with diagnosed depression we tested the validity of the ARH through assessing the influence of depressive rumination on mood, cognitive performance and electrophysiological correlates. Rumination was experimentally induced by expressive writing. In the control condition we used the distractive writing method. The results show a corresponding effect of rumination on the mood of our patients as expected. However, we were not able to see the proposed effects on cognitive abilities. KEY WORDS Depression, rumination, adaptation, cognition, affective state, neural correlates
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Influence of experimental intestinal dysbiosis on behavioral, neuroendocrine and immune properties of mice and the possibility of modifying it by administration of probiotic strain Escherichia coli O83:K24:H31
Avramová, Pavla ; Černý, Viktor (advisor) ; Roubalová, Radka (referee)
The gut microbiota is a key factor influencing the function of many organs in the human body, including the nervous, immune, and endocrine systems. This dynamic ecosystem can be modulated by diet, age, environment, even medication. The balanced composition of the microbiota is crucial for individual health, and its disruption leads to dysbiosis. The connection between the gut and the central nervous system is mediated by the microbiota-gut- brain axis. This axis consists of several pathways interconnected to mutually regulate their functions. Among the major components of the axis are the neural pathway, led by the vagus nerve, the immune pathway, and the endocrine pathway, including the HPA axis. Recent studies suggest that probiotic bacteria have the ability to partially rectify dysbiosis and alleviate its consequences for the organism. This thesis focuses on researching the impact of gastrointestinal tract microbiota on the behaviour, immunity, and neuroendocrine aspects of mice. It delves into experimentally inducing dysbiosis using antibiotics and subsequently addressing it with the probiotic bacterium Escherichia coli O83:K24:H31. The aim is to determine whether these probiotics can mitigate the adverse effects of dysbiosis on the immune and neuroendocrine systems, as well as behavioural...
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Qualitative analysis of students affects during Covid-19
SUCHAN, Vít
The bachelor's thesis focuses on the affects of university students during the covid-19 pandemic. The theoretical part of the thesis describes the pandemic situation in the Czech Republic, then deals with the effects on the psyche of the population in general and then describes risk groups and coping strategies of university students in more detail. Finally, it presents the results of studies carried out in the Czech environment. The empirical part presents statements from the extensive psychological research of Jupsycor, carried out by the Section of Psychology, Department of Pedagogy and Psychology of the Faculty of Education of the University of South Bohemia in České Budějovice.
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Evolutionary Design of EEG Data Classifier
Kuželová, Simona ; Jawed, Soyiba (referee) ; Mrázek, Vojtěch (advisor)
Tato diplomová práce se zaměřuje na vývoj efektivního klasifikátoru pro klasifikaci kandidátů na základě extrahovaných vlastností z elektroencefalografického (EEG) signálu. K dosažení tohoto cíle byl použit genetický algoritmus pro výběr příznaků a optimalizaci klasifikátorů na základě pěti kritérií: minimalizace počtu příznaků, minimalizace doby inference a maximalizace klasifikační senzitivity, specificity a přesnosti. Pro extrakci příznaků s cílem klasifikovat kandidáty jako trpící MDD, nebo jako zdravé, byla použita EEG data s otevřenýma očima 31 kandidátů trpících depresivní poruchou (MDD) a 28 zdravých kandidátů. Byly otestovány dva algoritmy, NSGA-II a NSGA-III. Navržený algoritmus pracoval se třemi kritérii, ale byly přidány dvě další kritéria - senzitivita a specificita. NSGA-III byl v tomto případě účinnější a byl použit v následujících experimentech. Byla zavedena omezení pro zlepšení parametrů a byly vyzkoušeny různé hodnoty pro pravděpodobnost mutace a křížení. Vygenerované klasifikátory dosáhly průměrné přesnosti 91.36 \%, senzitivity 91.82 \% a specificity 90.84 \%. V závěrečných experimentech byly nejčastěji používány kanály F3 a C3 a nejčastěji využívaným vlnovým pásmem byla gama frekvence. Výsledkem této práce jsou efektivní klasifikátory, které byly získány pomocí navrženého algoritmu, jenž využívá genetický algoritmus pro optimalizaci parametrů.
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Mud
Součková, Anežka ; Stanová,, Magda (referee) ; Mikyta, Svätopluk (advisor)
The practical part of this bachelor’s thesis is a book called Bahno. It contains drawings and texts which are metaphorically and factually connected to mud: as a matter in which dead organisms and plants decompose and which at the same time feeds the soil for new life to spring, as an endless search for answers on an endless amount of questions on the purpose and contents of existence. The period in which the texts and drawings were being created was a period of concentrated attention on the forms of mud, pop-cultural references and its other occurrences. A part of the intuitive mapping of mud was, among other things, a visit of a village called Bahno ("Mud"), taking samples of the local mud, viewing it under the microscope (taken photographs are contained in the book).
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Weight development in obese patients with mental illness
Starý, Kilián ; Kalinová, Nelly (advisor) ; Žůrková, Pavla (referee)
Introduction: Obesity and mental illness are serious health issues whose worldwide prevalence has been increasing in recent years. In particular, depression and anxiety can impair the capacity of obese patients to reduce weight, which is a necessary step in reducing the risk of life-threatening complications of obesity. Objectives: The main objective of this study was to investigate the effect of baseline mental illness on weight development. For this purpose, a group of obese patients with either depression or anxious- depressive syndrome was selected. Relative change in weight over a 1-year period was selected as the main variable for comparison. One secondary objective was to compare outcomes in patients with psychiatric comorbidity by diagnosis. The second one was to assess the interaction between mental illness and female sex as predictors of poor weight loss outcomes. Methods: Data was collected in the Obesitology centre at the III. internal clinic - endocrinology and metabolism, 1st Faculty of Medicine, Charles University and General University Hospital in Prague. The research group (n=27) was selected from patients who underwent reduction hospitalisation between 2014 and 2021. The same was true for the control group (n=27) of obese patients without a psychiatric diagnosis. For all patients,...
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The Impact of the Covid-19 Pandemic on Clients of Fokus Český Krumlov. Reactions of People with Mental Illness
KOLAROVÁ, Soňa
The thesis examines how selected clients of FOKUS in Český Krumlov perceived and coped with the Covid- 19 pandemic and related government measures. The theoretical part describes the needs of people with specific diagnoses such as schizophrenia, depression, neurotic, stress and somatoform disorders, and their functioning in everyday life. It also describes the FOKUS organization, the Covid- 19 pandemic and all the related government measures. The practical part analyses the research based on interviews with selected clients of FOKUS in Český Krumlov. The practical part summarises how these clients perceived their mental health during the pandemic and whether they felt the impact of government measures through the lens of their illness.
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Effect of antidepressants on placental monoamine homeostasis
Horáčková, Hana ; Štaud, František (advisor) ; Sumová, Alena (referee) ; Soukup, Ondřej (referee)
Charles University, Faculty of Pharmacy in Hradec Kralove Department of Pharmacology and Toxicology Candidate: Mgr. Hana Horackova Supervisor: prof. PharmDr. Frantisek Staud, Ph.D. Title of doctoral thesis: Effect of antidepressants on placental monoamine homeostasis Depression in pregnancy is an increasingly common problem and it is reported that up to 25 % of pregnant women suffer from depression and approximately 13 % are prescribed antidepressants. Currently, the most commonly prescribed antidepressants in pregnancy are selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs). However, the safety of these treatments is still controversial, as poor pregnancy outcomes such as organ malformations, increased incidence of neurological disorders, and preeclampsia have been reported in pregnant women taking antidepressants. However, knowledge of the responsible mechanisms is still lacking at present as they have not been sufficiently investigated. Although the effect of antidepressants on the availability of serotonin (5-HT), dopamine (DA) and norepinephrine in brain tissue has been extensively characterized in the literature, the interactions of antidepressants with placental monoamine transporters have not received attention to date. However,...
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