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Comparison of advanced analysis of fMRI data from oddball experiment
Fajkus, Jiří ; Jan, Jiří (referee) ; Provazník, Ivo (advisor)
This master´s thesis deals with processing and analysis of data, acquired from experimental examination performed with functional magnetic resonance imaging technique. It is an oddball type experimental task and its goal is an examination of cognitive functions of the subject. The principles of functional magnetic resonance imaging, possibilities of experimental design, processing of acquired data, modeling of a response of organism and statistical analysis are described in this work. Furthermore, particular parts of preprocessing and analysis are carried out using real data set from experiment. The main goal of this work is suggestion and realization of model, which enables advanced categorization of stimuli, considering the type of previous rare stimulus and the number of frequent stimuli within them. With its in-depth categorization, this model enables detail exploration of cerebral processes, associated mainly with attention, memory, expectancy or cognitive closure. The second point of that work is an evaluation of models of hemodynamic response, which are applied in statistical analysis of data from fMRI experiment. Comparison of basis functions, the models of hemodynamic response to experimental stimulation used for general linear model, is performed in this work. The result of this comparison is an evaluation of detection efficiency of activated voxels, false positivity rate and computational and user difficulty.
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Analysis of connections between simultaneous EEG and fMRI data
Labounek, René ; Kremláček,, Jan (referee) ; Lamoš, Martin (advisor)
Electroencephalography and functional magnetic resonance are two different methods for measuring of neural activity. EEG signals have excellent time resolution, fMRI scans capture records of brain activity in excellent spatial resolution. It is assumed that the joint analysis can take advantage of both methods simultaneously. Statistical Parametric Mapping (SPM8) is freely available software which serves to automatic analysis of fMRI data estimated with general linear model. It is not possible to estimate automatic EEG–fMRI analysis with it. Therefore software EEG Regressor Builder was created during master thesis. It preprocesses EEG signals into EEG regressors which are loaded with program SPM8 where joint EEG–fMRI analysis is estimated in general linear model. EEG regressors consist of vectors of temporal changes in absolute or relative power values of EEG signal in the specified frequency bands from selected electrodes due to periods of fMRI acquisition of individual images. The software is tested on the simultaneous EEG-fMRI data of a visual oddball experiment. EEG regressors are calculated for temporal changes in absolute and relative EEG power values in three frequency bands of interest ( 8-12Hz, 12-20Hz a 20-30Hz) from the occipital electrodes (O1, O2 and Oz). Three types of test analyzes is performed. Data from three individuals is examined in the first. Accuracy of results is evaluated due to the possibilities of setting of calculation method of regressor. Group analysis of data from twenty-two healthy patients is performed in the second. Group EEG regressors analysis is realized in the third through the correlation matrix due to the specified type of power and frequency band outside of the general linear model.
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Inverse values of EEG signal power in joint EEG-fMRI analysis
Sanetrníková, Dominika ; Kolář, Radim (referee) ; Labounek, René (advisor)
The first part of this thesis summarizes the basic theory of brain activity measurement using the BOLD signal and scalp EEG, the effect of noise phenomena in the data and its suppression, the merger of the fusion of the measured data using the general linear model and the current implementation of computational algorithms in the software library EEG Regressor Builder 1.0. Within the own solution of this thesis, the changes of the software library to version 1.1 were realized according to the requirements of the bachelor thesis. The hypothesis that temporal changes of the EEG relative band power (20 - 40Hz) has the same spatial correlates with the BOLD signal as the inverse power in the frequency range 0-12Hz. The hypothesis was rejected based on the calculation of similarity criterions between 3D activation maps for different parameter settings of the joint analysis calculations. As an appropriate criterions were chosen the correlation coefficient and the cosine criterion. The Euclidean distance was proved to be unfit. Also it was proved the inverse power value of EEG signal in the given frequency band brings to the common EEG-fMRI analysis an anti-correlated signal to the normal absolute power in the same frequency band. Furthermore the influence of regressors describing motion artifacts reduces the number of supra-thresholded voxels.
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Inverse values of EEG signal power in joint EEG-fMRI analysis
Sanetrníková, Dominika ; Kolář, Radim (referee) ; Labounek, René (advisor)
The first part of this thesis summarizes the basic theory of brain activity measurement using the BOLD signal and scalp EEG, the effect of noise phenomena in the data and its suppression, the merger of the fusion of the measured data using the general linear model and the current implementation of computational algorithms in the software library EEG Regressor Builder 1.0. Within the own solution of this thesis, the changes of the software library to version 1.1 were realized according to the requirements of the bachelor thesis. The hypothesis that temporal changes of the EEG relative band power (20 - 40Hz) has the same spatial correlates with the BOLD signal as the inverse power in the frequency range 0-12Hz. The hypothesis was rejected based on the calculation of similarity criterions between 3D activation maps for different parameter settings of the joint analysis calculations. As an appropriate criterions were chosen the correlation coefficient and the cosine criterion. The Euclidean distance was proved to be unfit. Also it was proved the inverse power value of EEG signal in the given frequency band brings to the common EEG-fMRI analysis an anti-correlated signal to the normal absolute power in the same frequency band. Furthermore the influence of regressors describing motion artifacts reduces the number of supra-thresholded voxels.
|
|
|
Analysis of connections between simultaneous EEG and fMRI data
Labounek, René ; Kremláček,, Jan (referee) ; Lamoš, Martin (advisor)
Electroencephalography and functional magnetic resonance are two different methods for measuring of neural activity. EEG signals have excellent time resolution, fMRI scans capture records of brain activity in excellent spatial resolution. It is assumed that the joint analysis can take advantage of both methods simultaneously. Statistical Parametric Mapping (SPM8) is freely available software which serves to automatic analysis of fMRI data estimated with general linear model. It is not possible to estimate automatic EEG–fMRI analysis with it. Therefore software EEG Regressor Builder was created during master thesis. It preprocesses EEG signals into EEG regressors which are loaded with program SPM8 where joint EEG–fMRI analysis is estimated in general linear model. EEG regressors consist of vectors of temporal changes in absolute or relative power values of EEG signal in the specified frequency bands from selected electrodes due to periods of fMRI acquisition of individual images. The software is tested on the simultaneous EEG-fMRI data of a visual oddball experiment. EEG regressors are calculated for temporal changes in absolute and relative EEG power values in three frequency bands of interest ( 8-12Hz, 12-20Hz a 20-30Hz) from the occipital electrodes (O1, O2 and Oz). Three types of test analyzes is performed. Data from three individuals is examined in the first. Accuracy of results is evaluated due to the possibilities of setting of calculation method of regressor. Group analysis of data from twenty-two healthy patients is performed in the second. Group EEG regressors analysis is realized in the third through the correlation matrix due to the specified type of power and frequency band outside of the general linear model.
|
|
|
Comparison of advanced analysis of fMRI data from oddball experiment
Fajkus, Jiří ; Jan, Jiří (referee) ; Provazník, Ivo (advisor)
This master´s thesis deals with processing and analysis of data, acquired from experimental examination performed with functional magnetic resonance imaging technique. It is an oddball type experimental task and its goal is an examination of cognitive functions of the subject. The principles of functional magnetic resonance imaging, possibilities of experimental design, processing of acquired data, modeling of a response of organism and statistical analysis are described in this work. Furthermore, particular parts of preprocessing and analysis are carried out using real data set from experiment. The main goal of this work is suggestion and realization of model, which enables advanced categorization of stimuli, considering the type of previous rare stimulus and the number of frequent stimuli within them. With its in-depth categorization, this model enables detail exploration of cerebral processes, associated mainly with attention, memory, expectancy or cognitive closure. The second point of that work is an evaluation of models of hemodynamic response, which are applied in statistical analysis of data from fMRI experiment. Comparison of basis functions, the models of hemodynamic response to experimental stimulation used for general linear model, is performed in this work. The result of this comparison is an evaluation of detection efficiency of activated voxels, false positivity rate and computational and user difficulty.
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