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The impact of compounds from cigarette smoke on blood coagulation in vitro
Afshari, Mohammadreza ; Carazo Fernández, Alejandro (advisor) ; Karlíčková, Jana (referee)
Charles University Faculty of Pharmacy in Hradec Králové Department of Pharmacology and Toxicology Student: Mohammadreza Afshari Supervisors: Pharm Dr Alejandro Carazo Fernández, Ph.D. Thesis title: The impact of compounds from cigarette smoke on blood coagulation in vitro Hemostasis is the physiological process that stops bleeding at the site of an injury while maintaining normal blood flow elsewhere in the circulation. It is characterized by the equilibrium between proteins, enzymes, and other biological factors. Hemostasis is one of the most important biological processes in our body and any alteration in the function can affect the health of the individual severely. Nowadays the world is experiencing an epidemy of cigarette smoking and many people are socially and economically affected by the health impact of cigarette smoking. Cigarette smoking has been proven to increase the chance of the development of various cardiovascular diseases such as atherosclerosis, coronary heart disease, stroke, and peripheral arterial disease, among others. Despite the large number of studies conducted on the effect of cigarette smoke on the cardiovascular system, there are only scarce studies that directly evaluate the effect and impact of cigarette smoke on the hemostasis and their effect on specific steps....
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