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National Repository of Grey Literature 2 records found  Search took 0.00 seconds. 
Maintenance of chromosomes integrity in Giardia intestinails as a model organism.
 Uzlíková, Magdalena ; Nohýnková, Eva (advisor) ; Lalle, Marco (referee) ; Stejskal, František (referee)
Giardia intestinalis is a protozoan causing diarrhea worldwide. Beside its medical importance, it is evolutionary distant protist with two nuclei within a cell adapted for parasitic life in the environment poor of oxygen. Its genome is small and compact in term of gene content and size. It is therefore an attractive model organism for studies of minimal requirements for cellular processes. Present work brings new partial information on different levels of chromosome integrity maintenance of this parasite. Our study presents characteristics of chromosome termini and their protection. We localized telomeres during all stages of the trophozoite cell cycle and determined the length of Giardia telomeres ranging from 0.5 to 2.5 kb, we proved an existence of an active telomerase enzyme synthesizing telomeric repeats in in this parasite, despite the fact that giardial telomerase is structurally divergent. Present data support the view that the chromosomal termini in Giardia are maintained in a conservative manner that is common to other eukaryotes. We described effects of commonly used drug for treatment of anaerobic infections, metronidazole, on DNA and cell cycle progression in susceptible and resistant cell lines. Incubation of cells with this drug causes phosphorylation of histone H2A in cell nuclei...
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Review of karyotype races of mole rats of the genera Spalax and Nannospalax and their geographic distribution
 Kučerová, Šárka ; Zima, Jan (advisor) ; Šťáhlavský, František (referee)
Mole rats are divided into two genera, Spalax and Nannospalax who live in the territory of South-East Europe and the Middle East. 5 different karyotypic races found in the genus Spalax that can be assigned to individual taxonomically recognized species. The genus Nannospalax has described in 83 karyotypic form or cytotypes that differ in fundamental characteristics of sets of chromosomes (2n, NF). The diploid number of chromosomes varies from 36 to 62, the number of autosomal arms from 62 to 120 and the number of arms of chromosome sets of females from 68 to 124. The three most commonly recognized species (Nannospalax leucodon, N. xanthodon, N. ehrenbergi) cannot clearly distinguish by karyological.
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