|
|
Induction of heme oxygenase and biological role of its metabolic products.
Šuk, Jakub ; Muchová, Lucie (advisor) ; Jirsa, Milan (referee) ; Neužil, Jiří (referee)
Heme oxygenase (HMOX) catalyzes first and rate-limiting step in heme degradation. By its action, carbon monoxide (CO), ferrous iron and biliverdin which is subsequently reduced to bilirubin are produced. Before discovery of HMOX reaction mechanism, CO was considered only a toxic waste product without any significant importance for human organism. Bilirubin, marker of liver dysfunction, has been also exposed to similar perception. But results from past decades show that HMOX and its metabolic products play an important role in number of physiological as well as defense against pathophysiological processes. The aim of this thesis was to clarify the role of HMOX and its metabolic products, presumably CO and bilirubin, in vivo and in vitro. We focused on the role of CO in a rat model of lipopolysaccharide-induced cholestasis. We were first to describe tissue distribution and pharmacokinetics of inhaled CO in this animal model and found out that CO inhalation is associated with anti-inflammatory and hepatoprotective effects. In a rat model of ethinylestradiol-induced cholestasis, we demonstrated the anticholestatic effect of HMOX. The induction of HMOX by its substrate heme increased the expression of liver transporters thereby increasing bile flow and simultaneously facilitated effective clearance of...
|
|
|
Utilization of carbon dioxide in power engineering
Svoboda, Kryštof ; Sitek, Tomáš (referee) ; Špiláček, Michal (advisor)
This bachelor thesis deals with the use of carbon dioxide as a source of energy in the form of carbonaceous fuels. The first part describes the possibilities of carbon dioxide capture and its subsequent storage. The second part is dedicated to the conversion of carbon dioxide to carbonaceous fuels. In the third and final part of the thesis, these fuels are then evaluated for their utilization and compared with commonly used fuels.
|
|
|
Care of pacients intoxicaded by carbon monoxide
FORMANKA, Matěj
The topic of this thesis is the care of the patients intoxicated with carbon monoxide. Carbon monoxide ranks first among random poisonings in Europe. Therefore it is a significant socio-economic problem. The thesis is divided into the theoretical and practical part. The theoretical part describes the physical features of carbon monoxide and the ways it reaches the human body. It also describes the anatomy of the respiratory tract, breathing physiology and pathophysiological processes in the human body that are caused by carbon monoxide. The thesis describes possible sources of carbon monoxide, clinical symptoms of poisoning, diagnosis and treatment methods. In the practical part, the research is conducted using a qualitative method - interviews. The practical part has two goals. The first goal is to map the level of paramedics' knowledge of carbon monoxide intoxication. The second goal is to find out if paramedics are able to provide patients poisoned by carbon monoxide with adequate care and also to find out what care is given to them. The research sample consists of two groups of respondents. The first group is paramedics working in pre-hospital emergency care and the other are nurses working in the intensive care unit. Research has shown that respondents have good knowledge of carbon monoxide poisoning. The greatest drawbacks were found in the knowledge of the pathophysiology of carbon monoxide poisoning. The most of the problems were related to these drawbacks. In a field of care have been discovered some facts, that could cause problems. For example, the fact that there is only one hyperbaric medicine center in the whole Moravia region or the lack of CO-oximeters in the paramedics' equipment.
|
|
|
Care of pacients intoxicaded by carbon monoxide
FORMANKA, Matěj
Theme of this bachleor thesis is care of pacients intoxicaded by carbon monoxide. Carbon monoxide occupies the fist place among accidental poisoning in Europe. This means, it is a big social-economic problem. Theoretical part describes physical attributes od carbon monoxide a his ways, by which it enters the human body. Further it describes the anatomy of airways, physiology of breathing and pathophysiological proces, which carbon monoxide causes in human body. There are described posibble sources of carbon monoxide, clinical symptoms, diagnostics and a way of threatment. In practical part, the research is processed by qualitative method using dialog. The practical part had two objects. The first object was to chart a level of knowlege of health professionals about carbon monoxide poisonning. The second object was to find out, if health professionals are able to provide an adequate care to pacients intoxicaded by carbon monoxide and to find out what kind of care is provided to pacients. The research sample was formed by two groups of respondents. The first group were paramedics, who work in pre-hospital emergency care. The second group were nurses, who work on a intensive care unit in a hospital. The research showed that the respondents have quite good knowlege about carbon monoxide poisoning. The biggest deficiency was discovered in knowlege of phatophysiology of carbon monoxide poisonynig. Most ignorace was related to this problem. In knowlege and provision of care were found some facts, which can cause problems. For example the fact, that there is ony one hyperbaric oxygen therapy centre in a whole Moravia, or missing pulse co-oxymeters in paramedics quipment.
|
|
|
Emissions from biomass combustion
Ptáček, Pavel ; Lisá, Hana (referee) ; Baláš, Marek (advisor)
Bachelor thesis deals with production of gaseous emissions from biomass combustion. It describes how emissions arise and how they affect human health and environment. In experimental part of the thesis emissions were measured and compared for different types of fuel in two combustion devices. Emission classes of combustion devices were also determined.
|
|
|
The survey of selected parameters of the intervention of Fire Rescue Service of Prague in case of carbon monooxide presence
JOB, Lukáš
The association between intoxication by hazardous chemicals and selected parameters response of the Integrated Rescue System is currently a frequently discussed theme. This connection is especially observed where the main source of carbon monoxide poisoning. Fire and Rescue Service of the Czech Republic in cooperation with the Integrated Rescue System units solves a wide range of events every year just with the leakage of carbon monoxide. This gas was, and today still is the cause of much intoxication, especially when using Karma for water heating. That is the reason why this thesis focuses precisely on the investigation of selected parameters response of the Fire and Rescue Service of the capital City of Prague upon the carbon monoxide occurrence. Important factors influencing the progress of the intervention is i.a., knowledge of the toxic effects of this gas and its effects on the human body, but also adequate quantity and quality of the detection devices and protective equipment. This diploma thesis deals with the investigation of selected parameters mentioned above emergency interventions, be subsequently treated by in the period from 2010 to 2014 under the Fire and Rescue Service of the capital City of Prague. The theoretical part describes the hazardous chemical substance (carbon monoxide) in terms of chemical, physical, biological, and also its use. The important part is the detailed description of the intoxication of carbon monoxide in the organism, the degradation of the organism, consequences of poisoning and medical procedures. Further have been also described respiratory protective devices, which are focused on the protective filters. When processing the diploma thesis is also found all events with the release of carbon monoxide in the capital City of Prague territory. These data are based on the statistical monitoring of events that leads and processes Fire and Rescue Service of the capital City of Prague. From statistic of interventions are subsequently searched data on the number of killed, wounded and rescued persons who are within the statistics registered. As comparative parameters are selected data on average daily temperatures and average daily pressures in the capital City of Prague territory. These data are for the period provided by the Czech Hydrometeorological Institute, Prague subdivision. The diploma thesis is determined and verified hypotheses of influence of the average daily temperature on the frequency of interventions with the presence of carbon monoxide in the capital City of Prague territory in the monitored period, average daily pressures influence on the frequency of interventions with the presence of carbon monoxide in the capital City of Prague territory and affect of the average daily temperature on the average daily pressures. The gained information is comprehensively and detailed processed into tables. The events in tables are divided by years, months. Afterwards it provides a general overview of emergency interventions in the monitored period. The processed data are then statistically examined and evaluated. In the first part is determined statistical unit for the period of five years. The data are also tabulated together with the average temperature and the average pressure and then suitably scaled. Then calculation of the general moments of the first order, standard deviations and correlation analysis follows. The results are compared with prescribed intervals. Based on a comparison of the results with the prescribed intervals is evaluated that the number of events does not correlate with the temperature, so the number of events with a temperature not connected, the number of events is positively correlated with the pressure, which means that the number of events related to the pressure. The temperature correlates positively with the pressure, i.e., these two parameters together, purview within performed examination, related.
|
|
|
Measurement of of atmospheric pollution
Dohnal, Jan ; Zimáková, Jana (referee) ; Bača, Petr (advisor)
This thesis deals with methods of measuring air pollution for gaseous substances. It contains a theoretical analysis of various types of pollution. Classification of pollution sources according to several criteria. It focuses on the creation, harm, use of carbon monoxide and carbon dioxide associated therewith. Analysis of various methods of detection for both gases.
|
|
|
Influence of traffic volume and meteorological conditions on the air pollution
Vojtěchová, Ivana ; Kotlík, Josef (referee) ; Adamec,, Vladimír (advisor)
Transport, whose intensity year by year increase, has assuredly influence on air quality. This issue solution will be focused especially on localities burden with transport in urban areas. The contribution of transport to increased values of air pollution will be evaluated with regards to meteorological conditions. Background stations from Czech Hydrometeorological Institute categorization will be chosen such as comparative sites. Pollutants emitted from traffic such as particulate matter, nitrogen oxides and carbon monoxide will be observed except meteorological conditions.
|
|
|
The database of waste incinerators in Europe
Šaldová, Lenka ; Ručka,, Jan (referee) ; Hluštík, Petr (advisor)
The aim of this thesis is to describe modern technological processing lines MSW incinerators. Describe individual objects and their links with the principle of thermal combustion. Processes described in the process line will be: waste reception, storage and waste materials, waste pretreatment, loading of waste into the process, thermal treatment of waste, energy utilization and conversion, gas cleaning, disposal of residues from flue gas cleaning, gas discharge, monitoring and control emissions , cleaning and inspection of wastewater treatment and disposal of ash (kiln ash), discharge (disposal) of solid residues. In the second part of this database will be set up incinerators occurring in Europe with basic information (address, website, kiln type, number of lines, the amount of waste incinerated, etc.). The developed database will be created graphs for better clarity and comparison. The database will be accompanied by the emission requirements of individual countries according to the applicable domestic and European legislation.
|
|
| |
guest ::
