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Specifika chovu a využití border kolií v České republice
Kokešová, Klára
This bachelor thesis focuses on the Border Collie breed, specifics of its breeding, breed standard, possible working and sporting use and the most common diseases in this breed. The practical part focuses on osteochondritis dissecans (OCD), which is a relatively common disease in this breed, but it's not a disabling defect for breeding. Information on a total of 108 individuals is collected by questionnaire and the information found is processed into graphs. The data shows that most of the individuals affected by OCD also have this disease in their ancestors. One of the other interesting obtained information is that most of dogs do not have their results from the examination on the presence or absence of OCD entered in the official Czech database of border collies. This fact represents a complication for future breeding if we want to at least partially prevented this disease. The thesis concludes with recommendations for breeders and owners.
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Využití a výcvik ovčáckého psa
ZIKMUNDOVÁ, Michaela
The bachelor thesis deals with the issue of the use of a dog in competitive herding, which is based on the use of a dog on the farm and to verify its ability to control the herd. Furthermore, the thesis describes the characteristics of breeds that are used for herding. The training of the monitored dog was carried out in 5 stages at 2 training centers under the guidance of experienced instructors. In the second phase, the dog passed the unofficial Natural Herding Aptitude Test (NHAT), with the rating "passed" in the Socialization section and "excellent" in the Shepherd Talent section. The training was completed by successful completion of unofficial competition with fourth place out of 12 dogs. The most commonly used dog breeds are Border Collie, Australian Shepherd, and Smooth Collie. The possibility to attend training sessions in several training areas and to consult training with more instructors has a positive effect on the overall training progress. An integral part of the overall performance of the pair is the role of the handler, who must give commands to the dog in time and correctly estimate the situation. When complications occur while training, it is not advisable to force the dog to work, as it might loose interest. At the competition that test the readiness of the dog and the handler, the handler should try to stay calm, as stressed handler might negatively affect the performance of the dog by sending wrong body signals.
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Polymorfismus v genu MDR1 u border kolií
Trýznová, Alena
This thesis is focused on polymorphism of MDR1 gene c.-6-180T>G, which causes phenobarbital resistance. Phenobarbital is one of the most commonly used drug against epilepsy, which is one of the most common neurological disease in dogs with frequency between 0,5-5 % according to breed. This mutation has so far been detected only in the border collie breed, which manifests up to 30 percent resistance to the treatment of epilepsy. In the text is subscribed border collie breed, dog epilepsy and gene MDR1. Methodical part is focused on detection of the polymorphism in model population of 82 dogs. The results agree with previous studies and confirm frequency of mutant alleles 32 % within the population.
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Testování mutací genů v asociasci k některým významným dědičným onemocněním u border kolie
KREJČOVÁ, Lenka
This diploma thesis summarizes knowledge of significant genetically contitioned deseases occurring in border collies. There is described a total of 14 diseases, some with the location of causal mutation not yet known. Primary focus of this thesis is g.4411956_4411960delGTTT mutation of gene VPS13B causing Trapped Neuthrophil Syndrome (TNS), MDR1 gene's mutation AF045016.1: c.227_230delATAG associated with multidrug resistance (MDR1) and CUBN gene's mutation c.8392delC which causes intestinal malabsorption of cobalamin by another name ImerslundGräsbeck syndrome (IGS). A genotype analysis of 89 border collies with a proof of origin was performed. The DNA was extracted from buccal mucosal swabs, the isolation of DNA was performed by Chelex-100 from the native material. The analysis was proceeded by optimized PCR-RFLP method using restrictive MboI (MDR1) and Msl I (IGS) enzymes. There were detected 4 g.4411956_4411960delGTTT mutation vectors causing TNS. As for the MDR1 and IGS there wasn't detected any affected case.
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Genetic determination of coat color in Border Collie
Hronová, Michaela ; Hofmanová, Barbora (advisor) ; Fiala Šebková, Naděžda (referee)
This bachelor thesis should serve as literature review or better say as scholarly introduction to genetic determination of fur in dgo with focusing on Border Collie breed. The thesis itself is divided to several parts. First on eis trying to introduce main pigment types synthesis, then an overview of genes affecting coat color in dogs is given. Next article is determined to versatile use of Border Collies and basic informations on the status of this breed in the Czech Republic. The last part is focused on fur color related genetic diseases. Thanks to the ongoing research of this field, I used some geneticly unverified sources.
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Trapped Neutrophil Syndrome in a Border Collie Dogs
Brunclíková, Tereza ; Krejčířová, Romana (advisor) ; Chmelíková, Eva (referee)
Border Collie comes from the part of the United Kingdom which is called Border Country. It's a herding dog, which should be obedient, smart, lively, and attentive. For breeding, Border Collies must fulfil bonitation conditions. One of the mandatory tests is the test on hereditary neutropenia. Hereditary neutropenia is a disease which causes a fatal immune system failure.
Immunity; or defences; is one of the basic features for survival. Basic ability of cells of the immune system is to recognize when in contact with other molecules the structure is inherent or not. Memory, which is another ability of the immune system, ensures a prompter, more intensive, and quicker response when meets already identified antigen repetitively.
Neutrophils are granulocytes (a type of white blood cells), which contain granules. These granules have active substances which participate in inflammation and allergic reactions. Neutrophils are produced in the bone marrow. They are brought by bloodstream to the site of inflammation where they phagocytose bacteria.
Hereditary neutropenia (Trapped Neurophil Syndrome - TNS) is a hereditary autosomal recessive disease. Hereditary disease is transferred from parents to offspring. In an autosomal recessive disease a feature is transferred by a recessive allele. A monitored feature is phenotypically shown just with recessive homozygotes. Heterozygotes are with no clinical signs of the disease but they cannot be phenotypically distinguished from dominant homozygotes.
TNS is characterized by a significant lack of neutrophils in blood because they are not brought from the bone marrow into the blood circulation. This is caused by retention at the site of their origin - in the bone marrow.
It is assumed that all cases of TNS are derived from one ancestor because in the pedigrees they have the same ancestor in the past six generations.
Development of an affected dog is generally slowed down. Puppies have smaller size; and for TNS disease is typical a shape of facial skull which resembles a ferret. The individuals suffer from fever and swollen joints. Affected dogs are dying at an early age because of immune system failure.
It was found that hereditary neutropenia is very similar to Cohen syndrome, which is a human disease. Both diseases have similar symptoms; it has been proved that both are caused by mutation of the same gene.
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Geneticky determinované choroby u border kolií
Trýznová, Alena
The thesis deals with the description of genetically determined diseases affecting the Border Collie breed. The described diseases include Collie Eye Anomaly, Trapped Neutrophile Syndrome and Ceroid Lipofuscinosis. The individual sections describe their symptoms, history, therapy, diagnostics and genetic dispositions of individual diseases, genetic testing methods and numbers of tested individuals. The thesis deals with diseases that could not be diagnosed genetically until recently; however, thanks to developing methods of molecular genetics, they are commonly available to breeders and owners at present.
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