|
|
Influence of the time interval from the radiopharmaceutical administration on the bone / background activity ratio in the bone scintigraphy
ZAHOŘOVÁ, Tereza
Influence of the time interval from the application of radiopharmaceutical on the activity ratio of bone/backround during the skeletal scintigraphy. The presented thesis aims to demonstrate the effect of the selected time interval from the application of radiopharmaceutical until the start of whole body skeletal scintigraphy on the quality of examination of patients at the department of nuclear medicine at the Clinic of imaging methods in FN Pilsen. The ratio between the background and bone activity of patients will vary with the length of the interval between the application of radiopharmaceuticals and the beginning of imaging. We expect that with prolonging of the time interval the ratio between the background and bone activity will increase, which means a higher quality of your imaging in practise. The hypothesis of this thesis expects a differentiation of ratio between the background and bone activity depending on the time of initiating whole body scintigraphy from the time of application of radiopharmaceuticals. To determine the ratio value a reference file of males aged 25-65 years (year of birth from 1951 to 1991, the year of examination from 2013 to 2016), weighing 65-95 kg was created, where scintigraphy does not show pathology in the examined area of the skeleton or in the soft tissues on the left thigh. These patients were divided into two groups according to the time intervals between the application and the beginning of the whole body skeletal scintigraphy. The first group consists of 30 patients who were examined less than 120 minutes after the application of the radiopharmaceutical. The second group consists of 30 patients who were examined more than 120 minutes after the application of the radiopharmaceutical. Using the ROI technique, values from the areas L5, right femur and soft tissue structures on the left thigh are obtained. These values are then used to calculate the time intervals on the activity ratio of bone/backround and verify the hypothesis, which assumes that the ratio values between the above mentioned groups will be different. This difference should prove that a longer time interval between the application of the radiopharmaceutical and the beginning of scintigraphy will bring a higher quality of scintigraphic imaging. This qualitative factor will be beneficial both for patients and their physicians who have to describe these scintigrams.
|
|
|
Bone metastases
MELICHAROVÁ, Miroslava
This bachelor's thesis deals with the topic ?Bone metastases?. The topic is split into the theoretical and practical part. To understand better the whole topic, I describe in the theoretical part at first the general anatomy of the bone tissue, subsequently the structure and growth of bones. There are described individual types of bone shapes. Also the process of occurring metastases or primary tumors in surrounding tissue is described, way of spreading and growth of tumor cells in the bone tissue is specified. Moreover I specify the occurrence of bone metastases and their diagnostics. In the diagnostics we notice at first the clinical symptoms bringing the patient to the physician. Three targets were determined for this thesis. The first target was to find out the most frequent places of occurrence of bone metastases. The second target was to find out the most frequent diagnostic method. And the third goal was to find out the most frequently used type of treatment during the occurrence of bone metastases. Also research questions were postulated. Research question No. 1: Do the bone metastases occur most frequently in the parts of red bone marrow with a rich blood circulation? Research question 2: Are the bone metastases diagnosed more frequently at women? To acquire the results, the databases of patients of the hospital České Budějovice a.s. and the hospital Na Homolce in Prague, radio-diagnostics, radiotherapy wards and ward of nuclear medicine were used. In the radio-diagnostic ward in České Budějovice and in Prague it was necessary to go through the records of all the diagnosed patients who underwent X-ray, CT and MR examination in the years 2011, 2012 and the subsequent records of data of patients with described (by physicians) occurrence of meta-static process in skeleton. There are among the necessary recorded data: age, sex, primary diagnosis, location of bone metastases and the applied examination method. In the practical part of the bachelor's thesis, these data were processed in diagrams and subsequently answers to set targets and research questions were formulated. In the radio-therapeutic wards the records of patients with indication of palliative radiation for the year 2011, 2012 were checked and in case of finding a patient radiated by palliative method due to occurrence of bone metastases the information concerning the age, sex, primary diagnosis, location of bone metastases and the applied radiation method (targeted or half-body radiation) were recorded. The acquired information was processed into diagrams in the practical part of bachelor's thesis again. Unfortunately, from the department of nuclear medicine no information about the amount of performed bone scintigraphy for metastatic process in skeleton were acquired, only information about patients treated by radio-nuclides. The answer to the research questions 1, ?whether the most frequent place of bone metastases is the part of red bone marrow with a rich blood circulation? was given already in the information about the most frequent location of bone metastases, as in the adult age, the red bone marrow occurs most frequently in the vertebra bodies, pelvis bones, breast bone, rips, flat bone of scull and long bones, where the red bone marrow occurs in the joint ends and based on my research, the metastases were located most frequently in these places. The answer to the research question 2: ?Are the bone metastases diagnosed at women more frequently?? It followed from my research that more bone metastases were diagnosed at men. Also the information leaflet for lay public was elaborated to my bachelor thesis informing of symptoms, diagnostic methods and treatment of metastatic process in bones.
|
|
|
The Sacroiliac Joint Ratio. Determination of Normal Values.
MAŘÍK, Karel
Indices SI joint. Determination of normal values. The present thesis aims to establish normal values in adults without any pathological changes in the SI joint, LS spine and pelvis who are examined at the whole-body bone scintigraphy in the Department of Nuclear Medicine Hospital in Czech Budejovice. The SI joint is examined in patients with suspected inflammation in focusing on the joint activity with the whole-body scintigraphy of the skeleton. Then, using the ROI ratio, the ratio of the activity in the SI joint activity and the sacrum or L spine is calculated. The first hypothesis assumes that people without any pathology changes of the SI joint belong to the range of 1,0?1,4. To determine the normal values, a reference file was created based on data of people whose whole body scintigram showed no pathology in the LS spine and SI joint and without any clinical suspicions of SI joint inflammation. The people selected for this research had not suffered from Bechterew?s disease, pelvic trauma and LS spine, bearing altered bone metabolism in the LS spine or pelvis. Their age at the examination time ranged from 25 to 45 years. Applying the ROI technology, values were obtained from the areas of the right and left SI joint, from the L4 and os.sakrum to verify the second hypothesis. This hypothesis assumes that in order to determinate normal values in the SI joint it is better to make a comparison using os.sakrum than L4. Applying statistical calculations, normal values of the SI joint are determined from these areas. The values will assist in the diagnosis of inflammatory diseases of spine in patients who are examined at the scintigraphy in the Department of Nuclear Medicine Hospital in Czech Budejovice.
|
guest ::
