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National Repository of Grey Literature 1 records found  Search took 0.00 seconds. 
Cytotoxicity screen of the acyclic nucleoside phosphonates against bloodstream stage of \kur{Trypanosoma brucei} and validation of their putative target hypoxanthine/xanthine/guanine phosphoribosyltransferase
 MITTERMAYR, Martina
The aim of this study was to test several compounds of acyclic nucleoside phosphonates (ANPs), which are thought to inhibit the purine salvage pathway enzyme hypoxanthine/xanthine/guanine phosphoribosyltransferase (HGXPRT) of the bloodstream stage of Trypanosoma brucei. Further we intended to elucidate if HGXPRT enzymes are essential for the survival of the bloodstream T.brucei.
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