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National Repository of Grey Literature

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Studium významu a mechanismů zapojení získané imunity při nádorové imunoterapii založené na synergii agonistů TLR a ligandů stimulujících fagocytózu VENHAUEROVÁ, Anna This master thesis is focused on analysis of involvement of adaptive immunity during antitumour MBTA immunotherapy which is based on synergy of TLR agonist, anti-CD40 and phagocytosis stimulating ligands anchored into the tumour cells membrane. This immunotherapy was tested in murine pancreatic adenocarcinoma Panc02 model. The aims of this thesis were to analyse the tumor infiltration during therapy and examine the role of adaptive immunity using KO mice. Subsequently, the possibilities of strengthening immunotherapeutic effects using inhibitor of survivin YM155, betaglucans or anti-TGF in metastatic murine Panc02 model were tested. Detailed record

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