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Structural changes in the brain in people with multiple sclerosis and their association with clinical status
Veselá, Adéla ; Řasová, Kamila (advisor) ; Švojgrová, Andrea (referee)
Title: Structural Brain Changes in Multiple Sclerosis Patients and Their Clinical Implications The main objective: The aim of this thesis is to determine whether lesions of the corticospinal tract can affect motor skills such as balance and walking in people with MS, as measured by the clinical tests Timed Up and Go (TUG), Berg Balance Scale (BBS), and the 12-item Multiple Sclerosis Walking Scale (MSWS-12). Another aim was to determine whether a two-month facilitationn therapy would influence balance and walking assessed by TUG, BBS, and MSWS when the corticospinal tract is affected by lesions in people with MS. And whether the effect of a two-month facilitation therapy varies depending on the involvement of CST. Methods: This work is part of the study "Neuroproprioceptive "Facilitation, Inhibition" and Brain Plasticity (NEFAI)", registered under the number NCT04355663, for which paraclinical (magnetic resonance (MR) images) and clinical data (Timed Up and Go test (TUG), Berg Balance Scale (BBS), and the 12-item Multiple Sclerosis Walking Scale (MSWS) questionnaire) were obtained from people with MS between 2015 and 2017. Lesions on MR images of people with MS were delineated in the 3D slicer program as part of my bachelors thesis in 2022. For the master's thesis, these images are aligned in the...
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