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Výskyt (anti-)thyroidní aktivity ve vodním prostředí České republiky
 SMĚŠNÁ, Tereza
Xenobiotics present in the aquatic environment can exhibit hormonal activity and thus they have potential to disrupt endocrine system of aquatic organisms. The aim of this study was to perform the first monitoring of the occurrence of (anti-)thyroid activity in samples from surface waters from the Czech Republic and subsequently identify potential hot-spots of the occurrence of (anti-)thyroid activity. Samples were taken using passive samplers of the POCIS type from 21 localities in 17 rivers from the Czech Republic. Detection of (anti-)thyroid activity was performed using the (anti-)TRbeta-CALUX in vitro bioassay in which cells were exposed to reference substances and dilutions of extracts from passive samplers. Triiodothyronine was used as reference compound for thyroid activity, while deoxynivalenol was used as reference compound for anti-thyroid activity. Thyroid activity was not found in any of the surface water samples. Anti-thyroid activity was found in 38 % of the tested samples and ranged from 89 to 310 micrograms/l equivalents of deoxynivalenol. In this study, eight localities with anti-thyroid activity were identified in surface waters of the Czech Republic. The strongest anti-thyroid activities were found in the rivers Bílina, Odra a Svratka. In addition, samples from Texas (USA) were tested in this study. Samples were collected using passive samplers of the POCIS type from 12 localities in 4 rivers from Texas. Neither thyroid nor anti-thyroid activity was found in any of the surface water samples. Further research is needed to determine the compounds responsible for the detected anti-thyroid activities in Czech surface waters and to assess potential risk that the compounds responsible for these activities may pose to aquatic organisms.
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