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HLA typizace v klinické praxi - využití k testování predispozic k onemocněním autoimunitního typu
 VESELÁ, Dominika
Autoimmune diseases require the interplay of internal (genetic) and external (environmental) factors to develop and erupt. The essential genetic factors include HLA alleles, whose carrying is associated with a significant predisposition to the development of a specific autoimmune disease. This Master Thesis deals with the problematics of autoimmune diseases associated with HLA system. The practical part focuses on the examination of predisposing alleles related to celiac disease as one of the most widespread autoimmune disease, which many scientific teams are dealing with, but even in the Czech Republic there are not enough population studies of this disease. Thanks to data from genetic laboratory GENLABS s.r.o. in České Budějovice, ÚHKT and VFN in Prague it was possible to focus on such population study.
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