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Allergic phenotypes in patients with respiratory allergy evaluated by microchip ISAC technique
Porubová, Petra ; Andrýs, Ctirad (advisor) ; Drahošová, Marcela (referee)
Charles University Faculty of Pharmacy in Hradec Králové Department of Biological and Medical Sciences Author: Bc. Petra Porubová Supervisor: prof. RNDr. Ctirad Andrýs, Ph.D. Title of diploma thesis: Allergic phenotypes in patients with respiratory allergy evaluated by microchip ISAC technique Key words: allergic inflammation, allergen specific IgE, component resolved diagnostics, microchip, ISAC Background: The aim of this diploma thesis was to evaluate the sensitization profile in the group of pacients with allergic rhinitis and/or bronhial asthma and to identify possible differences between patients with different disease severity. Methods: ImmunoCAP ISAC was used to determine specific IgE antibodies against 112 allergen components. The evaluated group included 152 patients (57.9 % women) from the allergology outpatient office of the Department of Clinical Immunology and Allergology, University Hospital Hradec Králové. Results: The most common allergens in this group of patients were the components Phl p 1 (68,4 %) and Bet v 1 (65,1 %). Differences in the number of positive and negative reactions were demonstrated between patients with different severity of allergic rhinitis. Correlations were found between the number of positive/negative reactions and the severity of bronchial asthma. And the...
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Natural inhalations. Their position in balneology, physiotherapy and therapeutic physical education.
MICHLOVÁ, Magdaléna
This thesis deals with the natural inhalations and their position in balneology, physiotherapy and therapeutic physical education. It consists of the theoretical part which peeks into the topic of both types of inhalations - natural and synthetic. It also speaks about clima, climatic conditions and places that are suitable for natural inhalations. These places are mostly climatic spa. It focuses on the possible combinations of natural inhalations with other spa procedures, especially on outdoor activities that may increase the effects of natural inhalations. In the theoretical part of the thesis I point out to the wide variability of options for the combinations of natural inhalations with the therapeutic physical activities. Besides the spa physiotherapy and therapeutic physical procedures, there are a lot of options of leisure and wellness activities for natural inhalations if they take place in suitable climatic enviroment. The practical part collected data retrospectively, partly from the archives of the Clinical pharmacology department, Nemocnice České Budějovice a.s., partly from the participants of the Summer Recover Camp Slavkov, Blahonice, operated by Nemocnice České Budějovice a.s. Probands were the participants of the camp - 14 boys and 23 girls. NIOX device was used to assess the FeNO (fiction of exhaled nitric oxide) at participants in the beginning and in the end of the twelwe-days-stay in the recovery camp. This method can quantitatively evaluate the impact of natural inhalations, therefore it is a quantitative research. Based on this research which shows that there was decreased allergic inflamation of probands, we can say that it is very likely, almost certain, that the natural inhalations have curative impacts. This thesis might be used especially in spa or clinical practice of physiotherapists for acquiring some basic awareness and knowledge about possibilities of the use of natural inhalation and might help them to integrate natural inhalations in the therapy. Last but not least, it can be beneficial for the laic public as an informative and educational material.
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