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Synthesis of new guaiazulene derivatives
Počtová, Žofie ; Kotora, Martin (advisor) ; Smrček, Stanislav (referee)
Synthesis of new guaiazulene derivates (abstract) This bachelor thesis concerns preparation of new guaiazulene derivates. The purpose of this work was to try some already known reactions and some new ones. Acylation of guaiazulene was carried out and was followed by oxidation, decarboxylation, allylation, and Diels-Alder reaction of the prepared guaiazulene derivates. The desired products were obtained in acylation, oxidation, and allylation reactions. Characterization of the prepared substances was performed by using NMR, IR or MS techniques.
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Synthesis of new guaiazulene derivatives
Počtová, Žofie ; Kotora, Martin (advisor) ; Smrček, Stanislav (referee)
Synthesis of new guaiazulene derivates (abstract) This bachelor thesis concerns preparation of new guaiazulene derivates. The purpose of this work was to try some already known reactions and some new ones. Acylation of guaiazulene was carried out and was followed by oxidation, decarboxylation, allylation, and Diels-Alder reaction of the prepared guaiazulene derivates. The desired products were obtained in acylation, oxidation, and allylation reactions. Characterization of the prepared substances was performed by using NMR, IR or MS techniques.
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The function of palmitoylation of membrane proteins in immune cells
Hanusová, Zdeňka ; Otáhal, Pavel (advisor) ; Pavlů, Barbora (referee)
Protein palmitoylation is a post-translation modification, which typically regulates the protein interaction with a membrane; apart from that, it can have various functions in protein regulation. Process of this modification covers covalent attachment of palmitate to an aminoacid residue in the target protein; identity of the aminoacid than determines the palmitoylation type. Most common is modification of a cystein residue - in that case we speak about so-called S-palmitoiyation. The exceptionality of this lipid modification type is in the reversibility of the whole process; this enables for example trafficking regulation of many proteins between various membrane compartments and ragulation of proteins' function. In vivo, palmitoylation of many proteins is mediated by enzymes protein acyltransferases, while depalmitoylation is mediated by enzymes acylprotein thioesterases. Palmitoylated proteins can be identified in wide spectrum of cellular types, also in immune cells. Palmitoylation plays here an important role, especially in interaction of signal proteins with lipid rafts and the related modulation of protein's function. Significance has palmitoylation also as a dynamic process, which mediates the right identification of protein's subcellular localization. This work is a review and it's aim is...
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