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Experimental study and modelling of the transdermal penetration of active species from gels
Palanová, Veronika ; Opatřilová, Radka (referee) ; Sedláček, Petr (advisor)
This diploma thesis deals with design and experimental study of transdermal transport of pharmaceutically active agents from gel matrices, which contain humic substance in its structure. A model absorption membrane was represented by the skin of pig´s earlobes. The study of the release of active substances and Lignohumte was performed due to the vertical diffusion cells. The amount of released humic substance was characterized by UV-VIS method and the amount of released active agent from gel matrix was determined by HPLC-DAD. The most interesting finding of this diploma thesis was that Lignohumate enhances transdermal transport of active agents and supports their release from gel samples to the particular environment.
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Humic substances as active or auxiliary pharmaceutical component
Blahuš, Petr ; Kalina, Michal (referee) ; Sedláček, Petr (advisor)
This thesis examines the effect of the potassium lignohumate on the transfer speeds of analgesic drugs through the synthetic Strat-M® membrane. In order to examine the transfer of these substances, vertical diffusion cells were used and the final samples were analysed using UV-VIS spectrometer and HLPC. The intention of this thesis was to optimise the process of preparing diffusion cells, to compare the transfer speeds of pure active substances and active substances with the potassium lignohumate, and to compare the permeability of Strat-M® membranes, by using pig skin membranes which were used in the previous study that this thesis continues from. The primary discovery was that the lignohumate slowed down the transfer of active substances through the membrane.
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Humic substances as active or auxiliary pharmaceutical component
Blahuš, Petr ; Kalina, Michal (referee) ; Sedláček, Petr (advisor)
This thesis examines the effect of the potassium lignohumate on the transfer speeds of analgesic drugs through the synthetic Strat-M® membrane. In order to examine the transfer of these substances, vertical diffusion cells were used and the final samples were analysed using UV-VIS spectrometer and HLPC. The intention of this thesis was to optimise the process of preparing diffusion cells, to compare the transfer speeds of pure active substances and active substances with the potassium lignohumate, and to compare the permeability of Strat-M® membranes, by using pig skin membranes which were used in the previous study that this thesis continues from. The primary discovery was that the lignohumate slowed down the transfer of active substances through the membrane.
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Experimental study and modelling of the transdermal penetration of active species from gels
Palanová, Veronika ; Opatřilová, Radka (referee) ; Sedláček, Petr (advisor)
This diploma thesis deals with design and experimental study of transdermal transport of pharmaceutically active agents from gel matrices, which contain humic substance in its structure. A model absorption membrane was represented by the skin of pig´s earlobes. The study of the release of active substances and Lignohumte was performed due to the vertical diffusion cells. The amount of released humic substance was characterized by UV-VIS method and the amount of released active agent from gel matrix was determined by HPLC-DAD. The most interesting finding of this diploma thesis was that Lignohumate enhances transdermal transport of active agents and supports their release from gel samples to the particular environment.
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