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Formation of pole assymetry during the Xenopus laevis oocytes growing
Pácalová, Eliška ; Vávra, Jiří (advisor) ; Drutovič, David (referee)
A frog Xenopus laevis is an important model organism used in developmental and cell biology and physiology. Oocytes of this species are frequently used for study of mechanisms of oogenesis and membrane proteins. Through oogenesis an animal-vegetal axis is established by asymmetric distribution of determinant molecules which are important in embryogenesis and establishment for another body axes. The main aim of this thesis is to overview transport mechanisms for establishment of asymmetric molecule (especially mRNA) and organelles asymmetry to animal and vegetal poles and their regulation. Key words: Xenopus laevis, oocyte, animal pole, vegetal pole, cytoskeleton, intracellular transport, mitochondrial cloud, METRO, early pathway, late pathway
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