Home > Search Results: keywords:"Vincristine-induced Peripheral Neuropathy"
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National Repository of Grey Literature 2 records found  Search took 0.01 seconds. 
Level of motor skills in paediatric patients after treatment of acute lymphoblastic leukaemia and correlation with time factors of treatment, treatment protocol, rate of peripheral neuropathy and presence of aseptic necrosis
 Hrdoušková, Monika ; Jevič, Filip (advisor) ; Šrámková, Lucie (referee)
The aim of this diploma thesis was to evaluate the motor skills of pediatric patients after completing the treatment of acute lymphoblastic leukemia (ALL). The partial objectives were to evaluate the effect of neuropathy, the cumulative dose of vincristine, the time since the end of treatment, the age at the time of diagnosis and the effect of the presence of avascular necrosis on motor skills. The Bruininks-Oseretsky Test of Motor Proficiency Second Edition (BOT-2) was used to assess motor skills. Evaluation of the presence and rate of vincristine- induced peripheral neuropathy was performed using the Pediatric-modified Total Neuropathy Score and using neural conduction studies. The results of the study showed that patients with ALL did not show a significantly worse overall BOT-2 score compared to the normative data of the healthy population.
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Electromyographic and clinical evaluation of vincristine-induced peripheral neuropathy in pediatric patients after treatment of acute lymphoblastic leukemia and correlation with the Bruinkins-Oseretsky Test of Motor Proficiency Second edition
 Bořilová, Karolína ; Jevič, Filip (advisor) ; Pánek, David (referee)
Title: Electromyographic and clinical evaluation of vincristine-induced peripheral neuropathy in pediatric patients after treatment of acute lymphoblastic leukemia and correlation with the Bruinkins-Oseretsky Test of Motor Proficiency Second Edition Objectives: The aim of this work was to characterize the neurological consequences of vincristine-induced peripheral neuropathy (VIPN) clinically and electromyographically and to evaluate motor skills of pediatric patients after the end of treatment of acute lymphoblastic leukemia. We also determined the relationship between the results of the clinical and electromyographic evaluation of VIPN and the correlation with the results of motor skills tests. Methods: The study involved 35 probands (19 girls and 16 boys) with a mean age of 10.7 years (SD ± 4.3) and a mean time since the last dose of vincristine of 2.3 years (SD ± 1.2). VIPN was assessed using a clinical pediatric-modified Total Neuropathy Score (ped-mTNS) and nerve conduction studies (NCS). Motor skills were assessed using the Bruinkins-Oseretsky Test of Motor Proficiency, Second Edition (BOT-2). Results: The clinical presence of VIPN, according to ped-mTNS, was found in 20 % of probands. Abnormalities in nerve conduction studies were reported by 60.9 % of probands. Of these, 92.9 % had motor...
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