Home > Search Results: keywords:"The Carousel Maze"
Search:
Search Tips :: Advanced Search
Search collections:
Sort by: Display results: Output format:
National Repository of Grey Literature 1 records found  Search took 0.01 seconds. 
Using the Carousel Maze as a test of cognitive symptoms in an animal model of schizophrenia
 Buchtová, Helena ; Landová, Eva (advisor) ; Jiruška, Přemysl (referee)
Spatial behaviour of animals is used to model cognitive human abilities such as declarative learning and memory. Cognitive deficits accompany a number of neuropsychiatric disorders and their treatment is most problematic. Schizophreniais one of these disorders. Behavioral, neurochamical, and molecular evidence point to a critical role of the NMDA glutamatergic receptors in the pathogenesis of schizophrenia. Disruption of their function results in behavioral and physiological changes including dysregulation of the depaminergic neurotransmission. This fact is used to model schizophrenia-related symptoms by systemic administration of NMDA receptor antagonists. Models combining administration of these drugs with behavioral tests aimed at specific cognitive deficits are of particular interest. This thesis use existing evidence to show that the Carousel Maze is such a behavioral test, which uses dynamic spatial learning to test the ability to coordinate discordant information and specific use of the relevant cues.
Detailed record

Interested in being notified about new results for this query?
Subscribe to the RSS feed.
Digital Repository :: Search :: Submit :: Personalize :: Help
Powered by Invenio v1.1.2
Maintained by admin.invenio@techlib.cz
This site is also available in the following languages:
Česky  English