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Studium sekvencí genů zbarvení u činčil na základě homologie se sekvencemi vybraných savců
Poslušná, Michala
In domesticated animals there are many different coat colours and mutations, often connected with pleiotropic effects. The aim of this thesis named The study of colour genes sequences in chinchilla based on homology of human and mice sequences was describe molecular genetic principles of pigmentation, introduce genes involved in melanogenesis and influencing a melanin function, their structure, mutations and mention other mutations which change the phenotype. Informations about alleles TYR, TYRP1, TYRP2/DCT, agouti, AGRP, gene group MCR (MC1R-MC5R) and more are focused on human (Homo sapiens), mouse (Mus musculus) and chinchilla (Chinchilla lanigera). In these three species was compared selected genes sequences TYR and TYRP2/DCT, results were studied, commented and mutations, which are very specific, but there are some analogs between human and mouse, were highlighted.
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